Efficacy and Safety of Intravenous Paracetamol in Manament of Labour Pain

Efficacy and Safety of Intravenous Paracetamol in Manament of Labour Pain in a Low Resource Setting

to compare between the use of single dose of paracetamol and pethidine hydrochloride intravenously in management of labour pains

investigators conducted a randomized clinical study included including 96 primiparous women admitted to Obstetrics and Gynecology Department, Menoufia University Hospitals, starting the study from May 2019 to March 2020 to assess the use of paracetamol intravenously versus Pethidine HCL intravenously in management of intrapartum pain. After obtaining approval from the local ethics committee, women who agreed to participate gave their signed informed consent after explanation of the trial benefits and hazards

Inclusion Criteria:

• Primiparous
• aged 18-35 years,
• Term live singleton pregnancy,
• Vertex presentation,
• Spontaneous onset of labor at term 37-42 weeks gestation,
• In active phase of of 1st stage of labour (cervix dilatation 3- 4 cm).

Exclusion Criteria:

Clinical evidence of cephalopelvic disproportion

• Use of any kind of analgesia prior to study
• Any medical disorder during pregnancy (liver or kidney impairment)
• Induction of labor, Intrauterine fetal death
• Evidence of fetal distress
• Antenatal diagnosis of congenital malformation
• Previous history of hypersensitivity to either drug
• Extremes of age (i.e. below 18 or above 35)
• Multiple pregnancies
• Cervical dilatation more than 6 cm.