Aim of the study is to examine the feasibility of dental implant insertion in patients receiving high, adjuvant and low dose > 4 years.

The hypothesis of the present study is that dental implant therapy using submerged healing is feasible and predictable in patients receiving high, adjuvant or low dose AR for more than 4 years, as documented by clinical and radiographic signs of osseointegration after 3-4 months, sufficient implant stability for abutment connection, and implant survival rates comparable to those of healthy individuals after one year of prosthetic loading.

Inclusion Criteria:

• Patient with cancer or osteoporosis, treated with antiresorptive treatment.
• The patients should have sufficient compliance, this includes willingness to have the planned assessments
• The patient should have an expected life span at enrollment of at least 2 years.
• The local bone quality and quantity should be sufficient for implant insertion without bone augmentation and is classified according to the classification by Cawood & Howell 1988.

Exclusion Criteria:

• > 10 cigarettes daily
• HbA1c > 53 mmol/mol
• Poor oral hygiene
• Poor general condition: ECOG score 3 or 4.
• Poor prognosis: Expected survival <2 year is an exclusion cause.
• Presence of metastases of the liver brain.
• Poor local jaw bone quality acc. to Cawood classification stage 3 or 4.
• Unwillingness to comply with the planned assessments and recordings

Total or partial toothless patients treated with antiresorptive medication, treated at Copenhagen University Hospital due to treatment with high dose, adjuvant, or low dose > 4 years, antiresorptive treatment. The patients had former tooth extractions or resections of the jaw at our clinic.