Cardiovascular Analysis of PEM

Cardiovascular Analysis of Post-exertional Malaise

The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome (CFS) patients and determine how it relates to the common symptom of Post-exertional malaise (PEM). Subjects will complete a maximal exercise test on 2 subsequent days. Total blood volume will be measured prior to each exercise test, and patient with hypovolemia on day 1, will be randomized to either a saline or sham infusion prior to the 2nd exercise test. A total of 80 CFS patients will be enrolled.

Inclusion Criteria:

• Ages 25 to 60
• Meet the 2015 IOM case definition for ME/CFS

Exclusion Criteria:

• Patients with a medical cause for their fatigue
• Patients taking medications that would dampen cardiac response to exercise
• Patients with psychotic illness, bipolar disorder, or current major depressive disorder
• Patients with a history of anorexia or bulimia within 5 years of intake
• Patients with a history of alcohol or drug abuse within 2 years of intake