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Corneal asphericity is expressed numerically as the "Q-value". A minus value means that corneal curvature flattens towards the periphery and the cornea is prolate in shape, but when the curvature steepens towards the periphery, the cornea is oblate in shape and has a positive Q-value.
The current study evaluates the effect of LASIK eye surgery on corneal asphericity by comparing 2 software treatment platforms; the Q value customized ablation versus the conventional Wave-front optimized ablation in a fellow eye study pattern.
The standard excimer laser correction of myopia is associated with decreased visual quality in the form of a decrease in contrast sensitivity and night vision. This degradation of the visual quality is attributed to changes in the corneal asphericity that increase the high order aberrations (HOAs), such as spherical aberrations because it leads to shifting of the corneal asphericity towards the oblate shape.
The wavefront-optimized (WFO) profile avoids the creation of new HOAs, but it is not able to treat those which are already present pre-operatively.
The Q-adjusted treatments correct the sphero-cylindrical refractive errors and try to maintain the corneal asphericity at the same time, but like the WFO ablation profiles, it is limited to correcting the spherical aberrations and not the non-rotational symmetric HOAs.
Some studies compared Lasers of two different platforms on contralateral eyes of the same patient in order to minimize inter-patient differences such as corneal wound healing and corneal biomechanics. By exclusion of these inter-patient differences, a more accurate judgment on the outcomes can be achieved.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Custom Q treatment group | Active Comparator | For every patient, the eye with the greater myopic spherical equivalent (SE) will be assigned for the Custom-Q treatment group. |
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| Wave-front optimized (WFO) group | Active Comparator | For every patient, the other eye with the lesser myopic SE will be assigned for the WFO treatment group |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Femtosecond laser assisted LASIK eye surgery | Procedure | FS-LASIK eye surgery includes corneal flap creation with femtosecond laser using the Femtosecond laser WaveLight FS200 followed by excimer laser vision correction of the patient's refractive error using excimer laser WaveLight EX500. |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Q value | Pentacam evaluation of post-LASIK Q value | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative corneal thickness at the pupillary center | Pentacam evaluation of post-LASIK pachymetry at the pupil center | 6 months |
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Inclusion Criteria: Candidates for Laser vision correction (LVC) with
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mahmoud Abdel-Radi, MD | Assiut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| TIBA eye center | Asyut | 71516 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28187180 | Background | Piao J, Li YJ, Whang WJ, Choi M, Kang MJ, Lee JH, Yoon G, Joo CK. Comparative evaluation of visual outcomes and corneal asphericity after laser-assisted in situ keratomileusis with the six-dimension Amaris excimer laser system. PLoS One. 2017 Feb 10;12(2):e0171851. doi: 10.1371/journal.pone.0171851. eCollection 2017. | |
| 36320050 |
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| Mostafa MM, Abdelmotaal H, Abdelazeem K, Goda I, Abdel-Radi M. Q-value customized versus wavefront-optimized ablation in femtosecond laser-assisted LASIK for myopia and myopic astigmatism: a prospective contralateral comparative study. Eye Vis (Lond). 2022 Nov 2;9(1):43. doi: 10.1186/s40662-022-00312-3. |