Vascular Health and Risk Factors in Children With Down Syndrome

Vascular Health and Risk Factors in Children With Down Syndrome

This is a prospective, multicenter, cross-sectional study to evaluate prevalence of vascular risk factors in children with Down Syndrome and to determine the association between vascular disease risk factors and objective markers of early atherosclerosis.

Inclusion Criteria:

• All children with Down Syndrome (10.0-18.0 years of age)
• Children with translocations and mosaicism
• Children with and without CHD

Exclusion Criteria:

• Patients with a history of hypoplastic arch, coarctation or catheter or surgical based aorta interventions
• Patients who are currently treated or have been treated with chemotherapy for cancer or a myeloproliferative disorder within 1 year of the study
• Participants whose parent/legally authorized representative (LAR) perceives the child is not able to cooperate with vascular imaging studies