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The aim of this present study is to compare functional results and quality of life after sigmoidectomy for diverticulitis and sigmoid cancer.
Rectal resection surgery can lead to numerous complications in term of gastrointestinal results with onset of fecal incontinence or in contrast constipation, and in term of genitourinary results with occurrence of dysuria, erectile dysfunction, or vaginal dryness. The low anterior resection syndrome is defined by the occurrence after rectal resection, of gastrointestinal symptoms like fecal incontinence or stool evacuation difficulties, which affect quality of life, despite conservation of anal sphincter. This syndrome is now well known and used in many countries.
However, there is a lack of data concerning gastrointestinal functional results after sigmoid surgery whether it is for cancer or diverticulitis. Some studies highlighted symptoms persistence in many patients after sigmoidectomy. Lately, the LARS score was used after sigmoidectomy for cancer. This study reveals symptoms of low anterior resection syndrome for 41 % of patients. The correlation between rectal resection and sigmoidectomy could be explain by the resection of the upper part of rectum in case of sigmoidectomy.
The issue of genito-urinary disorders after sigmoidectomy are poorly researched. Previous studies demonstrate a higher risk of erectile disorders after pelvic surgery and especially for cancer.
Currently, there is a lack of data on functional results and quality of life for patients who are going into sigmoid surgery, whether for cancer or diverticulitis. The aim of this longitudinal study is to compare digestive functional outcome, genitourinary outcomes and quality of life in patients who undergo sigmoid resection for diverticulitis and cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sigmoidectomy for sigmoid cancer | Sigmoid resection surgery for patients who suffer from sigmoid cancer |
| |
| Sigmoidectomy for diverticulitis | Sigmoid resection surgery for patients who suffer from symptomatic diverticulitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sigmoidectomy | Procedure | The sigmoid resection surgery, realized by laparoscopy or laparotomy, with anastomosis. |
|
| Measure | Description | Time Frame |
|---|---|---|
| LARS score | To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence. | At the visit of preoperative |
| LARS score | To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence. | At the visit of one month |
| LARS score | To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence. | At the visit of three months |
| LARS score | To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence. | At the visit of six months |
| LARS score | To measure incontinence troubles after low anterior resection. The score is from 0 to 42. The higher the score, the worst the incontinence. | At the visit of twelve months |
| Measure | Description | Time Frame |
|---|---|---|
| Bristol stool chart | A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea. | At the visit of preoperative |
| Bristol stool chart |
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Inclusion Criteria :
Exclusion Criteria :
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Patients suffered from sigmoid cancer or symptomatic diverticulitis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emilie DUCHALAIS-DASSONNEVILLE, PH | Contact | 33240084322 | Emilie.DASSONNEVILLE@chu-nantes.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Caen University Hospital | Recruiting | Caen | Calvados | 14000 | France | |
| Nantes University Hospital |
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| ID | Term |
|---|---|
| D012811 | Sigmoid Neoplasms |
| D004238 | Diverticulitis |
| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
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A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea. |
| At the visit of one month |
| Bristol stool chart | A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea. | At the visit of three months |
| Bristol stool chart | A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea. | At the visit of six months |
| Bristol stool chart | A scale to classify the form of the stools in seven category which indicate constipation or diarrhea in function of the type. Types 1 and 2 indicate constipation, types 3 and 4 are normal stools, type 5, 6 and 7 indicate diarrhea. | At the visit of twelve months |
| GIQLI | Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life. | At the visit of preoperative |
| GIQLI | Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life. | At the visit of one month |
| GIQLI | Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life. | At the visit of three months |
| GIQLI | Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life. | At the visit of six months |
| GIQLI | Quality of life related to gastrointestinal symptoms. Score from 0 to 144. The higher the score, the better the quality of life. | At the visit of twelve months |
| SF-36 | General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability. | At the visit of preoperative |
| SF-36 | General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability. | At the visit of one month |
| SF-36 | General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability. | At the visit of three months |
| SF-36 | General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability. | At the visit of six months |
| SF-36 | General quality of life score. Described with 8 scaled scores, which are : vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, social role functioning, mental health. Each scale score is from 0 to 100. The higher the score the less disability. | At the visit of twelve months |
| FSFI | Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function. | At the visit of preoperative |
| FSFI | Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function. | At the visit of one month |
| FSFI | Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function. | At the visit of three months |
| FSFI | Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function. | At the visit of six months |
| FSFI | Measure of sexual functioning in women. Score from 0 to 95. The higher the score, the better the sexual function. | At the visit of twelve months |
| ICIQ-FLUTS | Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence. | At the visit of preoperative |
| ICIQ-FLUTS | Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence. | At the visit of one month |
| ICIQ-FLUTS | Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence. | At the visit of three months |
| ICIQ-FLUTS | Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence. | At the visit of six months |
| ICIQ-FLUTS | Questionary for evaluating female lower urinary tract symptoms and impact on quality of life. Score from 0 to 48. The higher the score, the worst the urinary continence. | At the visit of twelve months |
| IPSS | Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function. | At the visit of preoperative |
| IPSS | Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function. | At the visit of one month |
| IPSS | Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function. | At the visit of three months |
| IPSS | Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function. | At the visit of six months |
| IPSS | Questionary to screen and manage symptoms of benign prostatic hyperplasia. Score from 0 to 35. The higher the score, the worst the urinary function. | At the visit of twelve months |
| IIEF5 | Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function. | At the visit of preoperative |
| IIEF5 | Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function. | At the visit of one month |
| IIEF5 | Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function. | At the visit of three months |
| IIEF5 | Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function. | At the visit of six months |
| IIEF5 | Questionary about erection problems on patient's sex life. Score from 1 to 25. The higher the score, the better the sexual function. | At the visit of twelve months |
| Recruiting |
| Nantes |
| Loire-Atlantique |
| 44093 |
| France |
|
| Angers University Hospital | Recruiting | Angers | Maine-et-Loire | 49000 | France |
| Vendée Departmental Hospital | Recruiting | La Roche-sur-Yon | Vendée | 85000 | France |
| D004067 |
| Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012810 | Sigmoid Diseases |
| D000076385 | Diverticular Diseases |
| D005759 | Gastroenteritis |