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ICU-Aw is highly prevalent (50%) among critically ill patients. Its diagnosis is usually delayed as it requires patients' awakening and collaboration to provide accurate measurement.
This study aims to investigate the accuracy of an early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation to diagnose future ICU-Aw in critically ill patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation (NMES) | Diagnostic Test | NMES will be applied to the quadriceps muscle to generate muscle contraction. Ultrasound measurement of the quadriceps thickness will be provided during contraction and rest, and the shortening of the quadriceps muscle will be measured. A second measurement using Shear-wave elastography measurement will also be undertaken. The measures will be undertaken at day 1 of neuromuscular blockers liberation (if any) as well as at day 3 and day 7 for the patients that will still be received mechanical ventilation at that time. |
| Measure | Description | Time Frame |
|---|---|---|
| ICU-Aw diagnosis | Measured with the Medical Research Council score (scored 0 (minimum) to 60 (maximum); with a score < 48 meaning ICU-acquired weakness) | In the 24 hours following extubation |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory muscles strength | Maximal Inspiratory Pressure and Maximal Expiratory Pressure | In the 30 minutes before extubation (during spontaneous breathing trial) |
| Cough capacity | Peak Cough Flow |
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Inclusion Criteria:
Exclusion Criteria:
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Critically ill patients admitted in ICU departement and mechanically ventilated for at least 24 hours without counterindications to provide NMES.
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| Name | Affiliation | Role |
|---|---|---|
| Yann Combret, PhD, PT | Groupe Hospitalier du Havre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Groupe Hospitalier du Havre | Montivilliers | 76290 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32366493 | Background | Medrinal C, Combret Y, Hilfiker R, Prieur G, Aroichane N, Gravier FE, Bonnevie T, Contal O, Lamia B. ICU outcomes can be predicted by noninvasive muscle evaluation: a meta-analysis. Eur Respir J. 2020 Oct 1;56(4):1902482. doi: 10.1183/13993003.02482-2019. Print 2020 Oct. |
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Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices).
Beginning after publication and ending 60 months following article publication.
For individual participant data meta-analysis. Proposals should be directed to yann.combret@gmail.com. To gain access, data requestors will need to sign a data access agreement.
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| In the 30 minutes before extubation (during spontaneous breathing trial) |
| Extubation failure/success | Reintubation or death | Within 48 hours after extubation |