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The aim of the study is to test the efficacy of a treatment for depression based on interpersonal psychotherapy (IPT). The treatment will be accessed via an internet platform built for this study. A therapist will provide support weekly, as well as on-demand when needed. The treatment lasts for 10 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interpersonal psychotherapy (IPT) | Experimental | 10 weeks of internet-administered interpersonal psychotherapy with therapist support. |
|
| Wait-list control group | No Intervention | The participants in the control group will receive access to the treatment after the post-treatment assessment has been conducted. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interpersonal psychotherapy | Behavioral | Internet-based interpersonal psychotherapy aimed at reducing symptoms of depression. The content of the intervention is divided into three parts: the assessment phase (the first four weeks), the focus phase (the following five weeks), and the end phase (the last week). |
| Measure | Description | Time Frame |
|---|---|---|
| Change on Montgomery Ã…sberg Depression Rating Scale (MADRS-S) | Depression inventory, consists of 9 items measuring symptoms of major depressive disorder. Each item are scored between 0 and 6 points, resulting in a total sum between 0 and 54. Cut-offs are: 0-12 No substantial depressive symptoms, 13-19 mild depressive symptoms, 20-34 moderate depressive symptoms, 35-54 severe depressive symptoms. | Before the treatment, during week 1 to 10 of the treatment, after 11 weeks. Follow-up one year after the start of the treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| Change on Beck Depression Inventory-II (BDI-II) | Depression inventory consisting of 21 items measuring symptoms of depressions along with behavioural and cognitive manifestations of these symptoms. Sum scores range between 0 and 63 points. Cut-offs: 0-13 minimal depressive symptoms, 14-19 mild depressive symptoms, 20-28 moderate depressive symptoms, 30-63 severe depressive symptoms. | Before treatment and after 11 weeks, follow-up one year after the start of the treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| Change on The Medical Outcome Social Support Survey, 12-item short form (MOS-SSS) | Mediational measure of perceived social support. Consists of six items summed up to a score between 12 and 60. Higher scores indicate more perceived social support. | Before the treatment, during week 1 to 10 of the treatment, after 11 weeks. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Behavioral Sciences and Learning, Linköping University | Linköping | Östergötland County | 58183 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39343313 | Derived | Kall A, Back M, Fahlroth O, Ekeflod E, Lundberg A, Viberg N, Andersson G. Internet-based therapist-supported interpersonal psychotherapy for depression: A randomized controlled trial. J Affect Disord. 2025 Jan 15;369:188-194. doi: 10.1016/j.jad.2024.09.171. Epub 2024 Sep 27. |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000079062 | Interpersonal Psychotherapy |
| ID | Term |
|---|---|
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| Change on Brunnsviken Brief Quality of Life Inventory (BBQ) | Measure of subjective quality of life. Sum scores can range between 0 and 96. Higher scores indicate a higher quality of life. | Before treatment and after 11 weeks, follow-up one year after the start of the treatment. |
| Change on Generalized Anxiety Disorder 7-Item Scale (GAD-7) | Seven item measure of generalized anxiety disorder. Sum score range from 0 to 21, with higher scores indicating more generalized anxiety. Cut-offs for interpretation: 0-5 minimal anxiety, 6-9 mild anxiety, 10-14 moderate anxiety, and 15-21 severe anxiety. | Before treatment and after 11 weeks, follow-up one year after the start of the treatment. |
| Change on Reflective Functioning Questionnaire-8 item version (RFQ-8) | Instrument measuring reflective functioning related to mentalization ability. Eight items where the respondent answers on a Likert scale. The scoring is calculated based on two scales, uncertainty and certainty. All eight items are scored twice, once for each scale. The Likert options for the scoring of the first scale is scored 0 0 0 0 1 2 3. The same items are then summed again with the scoring 3 2 1 0 0 0 0. All items are the summed up to give a measure of mentalization certainty and uncertainty. | Before treatment, after 11 weeks, following one year after the start of the treatment. |
| Score on Interpersonal Psychotherapy Outcome Scale (IPOS) |
Questionnaire asking the participant to identify the focus of the treatment and the perceived change in each focus area. Change is measured on a five-point Likert scale ranging from worsened significantly to improved greatly. |
| Measured 11 weeks after the start of the intervention. |
| Score on Credibility and Expectancy Questionnaire (CEQ) | Measure of the credible the participant perceive the intervention to be as well as how beneficial they expect it to be. Consists of six items, with four of them being answered on a nine-point Likert scale and two responses given on a ten-point Likert scale. Scores can range between 4 and 56, with higher scores indicating greater credibility and expectancy of positive change during the intervention. | Measured during week 3 of the intervention. |