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After vonoprazan (20mg/day) or esomeprazole (20mg/day) for 4weeks is prescribed for patients with erosive esophagitis diagnosed by esophagogastroduodenoscopy, the number of patients who will visit our outpatient clinic again due to some reasons without any appointments is compared with vonoprazan group and esomeprazole.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vonoprazan | Active Comparator | Vonoprazan (20mg/day) is prescribed for patients with erosive esophagitis |
|
| Esomeprazole | Placebo Comparator | Esomeprazole (20mg/day) is prescribed for patients with erosive esophagitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vonoprazan | Drug | Vonoprazan (20mg/day) is prescribed for 4 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The number of patients who revisit our outpatient clinic after the prescription without any appointments | The need to revisit our outpatient clinic again without any appointments may show the patients' satisfaction or dissatisfaction after the prescription of vonoprazan or esomeprazole. The difference in the number between the two groups may show the difference in the effectiveness between the two medicines. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the main symptom with patients after/before medication when the patients revisit again | The ratio of the degree of the main symptom after/before taking the medicine Good 0%- Bad 100% | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Questionnaire on satisfaction with taking the medicine at revisiting | The patient's satisfaction is assessed using visual analogue scale (Exellent 100% to very bad 0%). | 3months |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Showa Inan General hospital | Komagane | Nagano | 399-4191 | Japan |
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| ID | Term |
|---|---|
| D005764 | Gastroesophageal Reflux |
| ID | Term |
|---|---|
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| ID | Term |
|---|---|
| C552956 | 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine |
| D064098 | Esomeprazole |
| ID | Term |
|---|---|
| D009853 | Omeprazole |
| D053799 | 2-Pyridinylmethylsulfinylbenzimidazoles |
| D013454 | Sulfoxides |
| D013457 | Sulfur Compounds |
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| Esomeprazole | Drug | esomeprazole (20mg/day) |
|
| D004066 | Digestive System Diseases |
| D009930 |
| Organic Chemicals |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |