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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01CA240551-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Cancer Institute (NCI) | NIH |
| Johns Hopkins University | OTHER |
| Baystate Health |
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The goal of this research is to test the Adapt2Quit computer program that uses participant input (message rating on how much the text motivational message might influence one to quit smoking) to select and text motivational messages that are more likely to help a user stop smoking. This Adapt2Quit system will be compared with a quitline facilitation-only control (text messages will be sent to facilitate quitline use). The primary research hypothesis is that the Adapt2Quit recommender-selected messages will be more effective than a texting quitline facilitation-only control for smoking cessation among socioeconomically disadvantaged (SED) smokers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adapt2Quit | Experimental | These participants will receive Adapt2Quit motivational messaging and quitline facilitation messaging for 6 months. |
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| Control | Active Comparator | These participants will receive quitline facilitation-only messaging for 6 months. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adapt2Quit | Behavioral | Motivational text messages and quitline facilitation text messages will be sent to participants; these participants will receive Adapt2Quit (experimental) messages as well as quitline facilitation messages. |
| Measure | Description | Time Frame |
|---|---|---|
| Self-Reported Participant Tobacco Cessation Rate (quit rate) | Self-reported 6-month point prevalence cessation (yes/no) will be assessed at 6-month follow-up. | 6-months post-randomization |
| Biochemical Carbon Monoxide (CO) Verification of Tobacco Cessation | Biochemical carbon monoxide (CO) verification testing will also be done for a small subset of participants, where 0-6 parts per million (PPM) measures a non-smoker and 7+ PPM indicates a current smoker. | 6-months post-randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Time to First Quit Attempt | Self-reported date of first quit attempt since starting the study will be assessed through text message response from participant during the 6-month intervention period. | From randomization to 6-months post-randomization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rajani Sadasivam, PhD | Associate Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Baltimore | Maryland | 21287 | United States | ||
| Baystate Health |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40239194 | Derived | Kamberi A, Weitz B, Flahive J, Eve J, Najjar R, Liaghat T, Ford D, Lindenauer P, Person S, Houston TK, Gauvey-Kern ME, Lobien J, Sadasivam RS, Balakrishnan K. Testing a Machine Learning-Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2025 Apr 16;14:e63693. doi: 10.2196/63693. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 5, 2026 | |
| Reset | Jun 30, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 5, 2026 | Jun 30, 2026 | |||
| Jul 6, 2026 |
| ID | Term |
|---|---|
| D000073869 | Tobacco Smoking |
| ID | Term |
|---|---|
| D012907 | Smoking |
| D001519 | Behavior |
| D064424 | Tobacco Use |
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| OTHER |
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After completing the screening, informed consent, and baseline data collection, study staff will enter the participant identification number and participant mobile phone number from the survey into an online system, and the system will assign allocation based on the randomization table. Using this technique, both smokers and the staff will be blinded to allocation during the initial session. Then, the research staff will be un-blinded to provide personalized training for intervention and control (note that staff who complete follow-up will be different and blinded to group assignment).
| Control | Behavioral | Quitline facilitation text messages will be sent to participants; these participants will receive quitline facilitation-only messages. |
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| Springfield |
| Massachusetts |
| 01199 |
| United States |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | United States |