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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute Brain Injury Patients | Acute brain injury (ABI) patients will be recruited and studied using electroencephalogram (EEG) to monitor their brain response to auditory and visual stimuli. |
| |
| Healthy Volunteers | Healthy volunteers will serve as the control group and will undergo electroencephalogram (EEG) to monitor their brain response to auditory and visual stimuli. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Auditory stimuli | Diagnostic Test | Auditory stimuli (passive, active perturbations) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glasgow Outcome Scale-Extended (GOSE) Scale | The GOSE is an outcome scale, range 1-8 evaluating the patients' functional outcomes - higher score indicates better recovery | Up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Coma Recovery Scale - Revised (CRS-R) | The CRS-R will evaluate the patients' conscious state, range 0-23 -higher score indicates a better conscious state | Up to 5 years |
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Inclusion Criteria:
For ABI Participants
For Healthy Volunteers:
Exclusion Criteria:
For All Participants:
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Patients who present to the intensive care unit after ABI and are unconscious. Additionally, healthy volunteers will be recruited.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ayham Alkhachroum, MD | Contact | (305) 243-3218 | axa2610@med.miami.edu |
| Name | Affiliation | Role |
|---|---|---|
| Ayham Alkhachroum, MD | University of Miami | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jackson Memorial Hospital | Recruiting | Miami | Florida | 33136 | United States |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D002543 | Cerebral Hemorrhage |
| D003128 | Coma |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Columbia University | Recruiting | New York | New York | 10032 | United States |
|
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014474 | Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |