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| Name | Class |
|---|---|
| Edward Via College of Osteopathic Medicine-Auburn | UNKNOWN |
| The Peanut Institute | OTHER |
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This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in untrained men and women ages 18-30
This is a two-phase study using both novel and conventional methods to assess how PP supplementation affects muscle tissue in young adults who engage in resistance training. These two phases will be conducted as part of a 10-week randomized controlled trial in which men and women aged 18-30 years (n=40), will be stratified by gender and randomized to a resistance training intervention (whole body, two days per week) with PP powder (72g daily; n=10 males, n=10 females) provided during the intervention (immediate group, IG) or after the intervention (wait-list control, WLC, n=10 males, n=10 females). The aims of this study are to determine the acute (deuterium oxide tracer) and chronic (peripheral quantitative computed tomography) effects of PP during resistance training on skeletal muscle myofibrillar protein synthesis rates, changes in skeletal muscle size and quality, changes in whole and appendicular body composition (dual energy x-ray absorptiometry), changes in inflammatory markers and the fecal microbiome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Immediate Intervention Group | Experimental | Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder (72g/day) will be provided for daily consumption during the study period |
|
| Wait-list Control Group | Active Comparator | Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder will be provided after the study period |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peanut protein powder | Dietary Supplement | Peanut protein powder will be provided to participants who will be instructed to consume 72g daily, mixed with water |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in acute myofibrillar protein synthesis rates | Change in right leg vastus lateralis myofibrillar protein synthesis rates using the integrated deuterium oxide technique from biopsies immediately before and 24 hours after resistance exercise Change in right leg vastus lateralis myofibrillar protein synthesis rates using the integrated deuterium oxide technique from biopsies immediately before and 24 hours after resistance exercise | 24 hours |
| Change in mid-thigh skeletal muscle area and quality | Peripheral quantitative computed tomography (pQCT) cross-sectional image of mid-right thigh assessed for overall muscle density (mg/cm^3) | 0-10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in appendicular lean mass | Change in lean mass (kg) of limbs as measured by dual energy x-ray absorptiometry (DXA) | 0-10 weeks |
| Change in Type I and II Muscle Fiber Cross-Sectional Area |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael D Roberts, PhD | Associate Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Auburn University | Auburn | Alabama | 36849 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34836236 | Derived | Sexton CL, Smith MA, Smith KS, Osburn SC, Godwin JS, Ruple BA, Hendricks AM, Mobley CB, Goodlett MD, Fruge AD, Young KC, Roberts MD. Effects of Peanut Protein Supplementation on Resistance Training Adaptations in Younger Adults. Nutrients. 2021 Nov 9;13(11):3981. doi: 10.3390/nu13113981. |
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Deidentified anthropometric, physiological, biological and performance data may be requested
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Intervention group will receive the supplement during the study period and the wait-listed control group will receive the supplement after the study period. Both groups will participate in resistance training during the 10 week period
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PI and Co-Is will be blind to participant randomization. One study staff member will be responsible for administering the supplements to participants per randomization
| Full body resistance training | Behavioral | Participants will undergo supervised resistance training two times per week (5 exercises, 3 sets of 8-12 repetitions per set) |
|
Muscle biopsy immunofluorescent staining for determination of type I and type II muscle fiber cross sectional area (fCSA) as a cellular determinant of skeletal muscle hypertrophy
| 0-10 weeks |
| Change in leg extensor isokinetic dynamometry | maximal isokinetic right leg extensions on an isokinetic dynamometer (BioDex) | 0-10 weeks |
| Change in fecal microbiome composition | alpha- and beta-diversity of 16S bacterial rDNA | 0-10 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |