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| Name | Class |
|---|---|
| Aswan University Hospital | OTHER |
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Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.
This case -control observational prospective study will conducted on 40 patients with PD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GROUP 1 | Group 1 (patients with PD) All participants will be subjected to thorough history taking, full clinical and neurological examination. Diagnosis of PD by using Brain Bank Criteria for diagnosis of Parkinson Disease , assessment of the severity of PD by using PDRS and evaluation of cognitive functions using MMSE. |
| |
| Group 2 | Group 2 (controls) All participants will be subjected to thorough history taking, full clinical and neurological examination. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SHMT1 polymorphism | Genetic | It is to identify the role of SHMT1polymorphism in PD and examine the relationship between it and Severity of PD. |
|
| Measure | Description | Time Frame |
|---|---|---|
| polymorphism of SHMT1gene | one year |
| Measure | Description | Time Frame |
|---|---|---|
| the role of SHMT1plymorphism in pathogenesis PD | one year | |
| Study the relationship of Shmt1 polymorphism to the severity of Parkinson disease | One year |
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Inclusion Criteria:
Exclusion Criteria:
Patients with parkinsonian plus syndrome
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patient with parkinson diisease
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Effat a Tony, MD | Contact | +201097330309 | effattony@aun.edu.eg | |
| abeer a tony, MD | Contact | +201005389084 | abeer.tony@aswu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Abeer a tony, MD | Assistant professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Effat abdelhady tony | Recruiting | Asyut | 71515 | Egypt |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |