Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography

EYE-SEP : Study of Social Cognition in Patients With Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography.

This study aims to:

• analyze prospectively the prevalence of subclinical oculomotor disorders (OMDs) in different phenotypes of Multiple Sclerosis (MS) and to study correlations with brain MRI T2 data.
• highlight link between modification of visual exploration strategies to decode emotions, and social behavioral disorders, in patients with demyelinating disease, from early to clinically definite stages.

Inclusion Criteria:

• Male or Female.

• 18 years old and above.

• Sufficient written and oral expression in French.

• Covered by a health insurance system

• Written informed consent signed by the patient.

• For the MS group:

  * Patient diagnosed according to diagnostic criteria established by Polman et al. (2010): Radiologically Isolated Syndrome compatible with MS (RIS), Clinically Isolated Syndrome compatible with MS (CIS), Relapsing-Remitting MS, Secondary Progressive MS, or Primary Progressive MS.

  * Hospitalized or coming to perform a consultation.

• For the control group: No cognitive impairment (non pathological Mini-Mental State Examination (MMSE), according to age, gender and socio-cultural level).

Exclusion Criteria:

• General anaesthesia within 3 months.

• Ophthalmological problems preventing a video-oculography examination.

• Oculomotor disorders:

  • For the control group: "fixation disorders" or "ocular tracking disorders".
  • For the MS group: atypical disorders.

• Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia.

• Other neurological or ophthalmological disorders than MS

• History of stroke.

• Psychotropic drugs consummation.