Functional Lung Imaging With DECT and 4DCT

Pilot Study to Assess Lung Function Using Perfusion Blood Volume Dual Energy CT and 4DCT Derived Lung Ventilation Imaging

The basic premise of this pilot study is to enroll 40 patients over 3 years who have Stage II, III, or IV non-small cell lung cancer and are planned for definitive treatment with concurrent chemoradiation where a contrast enhanced 4DCT is planned.

Inclusion criteria:

• Patients have histologic diagnosis of non-small cell lung cancer
• Patients have AJCC stage II, III or IV disease were the plan is to receive definitive concurrent chemoradiation to 60 Gy or higher
• Age > 18 years of age
• Patients are able to provide informed consent
• No additional lung radiation is planned until after the 2nd CT on this study (i.e. patient does not have a solitary pulmonary nodule or second primary that the plan is to undergo SBRT)
• Patient must have adequate kidney function to receive IV contrast (following institutional policy supplied by radiology). The cutoff level for serum creatinine is 1.6 mg/dL
• Negative urine pregnancy test before every CT scan

Exclusion criteria:

• Allergy to IV iodine contrast
• Severe claustrophobia
• Further thoracic radiation therapy is planned.