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This study is designed to test the effects of the combination of naringenin (from an extract of sweet oranges) and beta carotene on energy expenditure and glucose metabolism in a single human subject.
The subject will be treated for 8 weeks with the combination of naringenin + beta carotene.
We will conduct the following assessments before the treatment and at the end of eight weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Naringenin + Beta carotene | Experimental | Subject will ingest 300 mg naringenin three times/day and 6 mg beta carotene two times/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| naringenin and beta carotene | Dietary Supplement | Subject will ingest 300 mg naringenin three times/day and 6 mg beta carotene two times/day for eight weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Energy expenditure | Ventilated hood | Five hours |
| Incidence of Treatment-Emergent Adverse Events | Adverse events | Eight weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose metabolism | Oral glucose tolerance test with insulin | Three hours |
| Blood pressure | Ambulatory | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Frank L Greenway, M.D. | Pennington Biomedical Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31670603 | Background | Murugesan N, Woodard K, Ramaraju R, Greenway FL, Coulter AA, Rebello CJ. Naringenin Increases Insulin Sensitivity and Metabolic Rate: A Case Study. J Med Food. 2020 Mar;23(3):343-348. doi: 10.1089/jmf.2019.0216. Epub 2019 Oct 31. |
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| ID | Term |
|---|---|
| C005273 | naringenin |
| D019207 | beta Carotene |
| ID | Term |
|---|---|
| D002338 | Carotenoids |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 | Hydrocarbons, Acyclic |
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Case study in a single human subject
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| Body weight | Measurement of body weight | 16 weeks |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D053138 | Cyclohexenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D013729 | Terpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |