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| Name | Class |
|---|---|
| Turkısh Medicines And Medical Devices Agency | UNKNOWN |
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In this study, it is evaluated the effects of laser assisted new attachment procedure (LANAP) and low level laser therapy (LLLT) and on clinical, biochemical and radiographic parameters in addition to non-surgical periodontal treatment (NSPT).
The study was designed as a randomized-controlled, single-blind and parallel design consisting of 80 patients with chronic periodontitis. Study consists of 4 groups, with 20 patients in each group. Group 1 received only NSPT, Group 2 received NSPT+LANAP, Group 3 received NSPT+LLLT, and Group 4 received NSPT+LANAP+LLLT. Clinical measurements of patients and gingival crevicular fluid (GCF) were taken before treatment and after 1 and 3 months. In GCF, interleukin-1beta, interleukin-10 and vascular endothelial growth factor were analyzed. Standard periapical radiographs were taken for radiographic measurements.
In moderate (4-6 mm) and deep pockets (7 mm and above), it was found that all groups treated with laser significantly decrease pocket depth (PD) and clinic attachment level (CAL) compared to Group 1. Group 3 caused significantly less gingival recession than all other groups. There was no statistical difference between the groups in biochemical markers. Radiographic analysis revealed that only Group 2 achieved significant bone filling compared to Group 1.
Bot LANAP and LLLT application in the deep pockets provide an additional contribution to NSPT. It has been found that LLLT administration leads to decrease in PD by creating a minimum recession.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Other | scaling and root planning (SRP) was applied. |
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| LANAP Group | Active Comparator | After scaling and polishing, three LANAP stages were performed : In the first stage, Nd:YAG laser was applied. In the second stage, full mouth SRP procedure was performed. In the third stage, Nd:YAG laser was applied again. |
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| LLLT Group | Active Comparator | after SRP Low Level Laser Therapy was performed using Nd:YAG laser. |
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| LANAP+LLLT Group | Active Comparator | after scaling both LANAP and LLLT were applied. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nd:YAG laser | Device | For LANAP, the fiber optic tip of the Nd:YAG laser (1064 nm) (Fotona Fidelis AT, USA) was used. For LLLT R24 biostimulation handpiece tip (950-μm) Nd:YAG laser (1064 nm) was used. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level gain | The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it. | Baseline |
| Clinical attachment level gain | The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it. | 1 month |
| Clinical attachment level gain | The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it. | 3 month |
| Measure | Description | Time Frame |
|---|---|---|
| Probing depth | It is determined by measuring the distance from the gingival margin to the pocket base | Baseline |
| Probing depth | It is determined by measuring the distance from the gingival margin to the pocket base |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Serhat Köseoğlu | study manager | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Katip Celebi University | Izmir | 35000 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40259146 | Derived | Kaya Dadas F, Genc Kocaayan S, Saglam M, Dadas OF, Koseoglu S. Evaluating efficacy of laser-assisted new attachment procedure and adjunctive low-level laser therapy in treating periodontitis: A single-blind randomized controlled clinical study. Lasers Med Sci. 2025 Apr 22;40(1):208. doi: 10.1007/s10103-025-04457-0. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| SAP | No | Yes | No | Statistical Analysis Plan | Nov 22, 2018 | Jan 1, 2021 | SAP_000.pdf |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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single-blind randomized controlled clinical study
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Clinical measurements were performed by a masked calibrated researcher to provide blindness
| 1 Month |
| Probing depth | It is determined by measuring the distance from the gingival margin to the pocket base | 3 Month |
| Gingival index | For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues | Baseline |
| Gingival index | For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues | 1 Month |
| Gingival index | For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues | 3 Month |
| Plaque index | This index measures the thickness of plaque on gingival one third | Baseline |
| Plaque index | This index measures the thickness of plaque on gingival one third | 1 Month |
| Plaque index | This index measures the thickness of plaque on gingival one third | 3 Month |
| Bleeding on probing | In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva. | Baseline |
| Bleeding on probing | In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva. | 1 Month |
| Bleeding on probing | In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva. | 3 Month |
| Interleukin-1beta | IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator. | Baseline |
| Interleukin-1beta | IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator. | 1 Month |
| Interleukin-1beta | IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator. | 3 Month |
| Interleukin-10 | IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects. | Baseline |
| Interleukin-10 | IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects. | 1 Month |
| Interleukin-10 | IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects. | 3 Month |
| vascular endothelial growth factor (VEGF) | VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis. | Baseline |
| vascular endothelial growth factor (VEGF) | VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis. | 1 Month |
| vascular endothelial growth factor (VEGF) | VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis. | 3 Month |
| Radiographic bone fill | The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography. | Baseline |
| Radiographic bone fill | The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography. | 1 Month |
| Radiographic bone fill | The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography. | 3 Month |