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This open label, prospective observational, single-center registry is to study short-, intermediate-and long-term course of postpartum hypertension and predictors/risk factors associated with long term cardiovascular and renal risk.
Current disease management strategies will be evaluated.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Data collection for parameters of organ damage (cardiac and renal blood markers) | Other | Blood results will be taken out of next routine venipuncture. Routinely collected standard parameters are a blood count, chemistry panel including renal parameters and electrolytes, lipid profile and a HbA1c as well as albumin/creatinine and protein/creatinine ratio in urine. | ||
| Data collection for blood pressure (BP) | Other | Clinic blood pressure and 24hour BP Measurements | ||
| Home-based blood pressure management (substudy) | Other | Subjects participating in home-based blood pressure management via telemonitoring will receive a free HekaHealth application (App) for the structured assessment of HBPM. | ||
| Biomarker Profiles (substudy) | Other | Substudy where possible cardiac, renal and pregnancy related biomarkers will be additionally analyzed. The following biomarkers will be analyzed: N terminal (NT)-proBNP, Troponin, elevated mid-regional pro-atrial natriuretic peptide (ANP), elevated mid-regional pro adrenomedullin (ADM), soluble fms-like tyrosine kinase (sFlt-1), and placenta growth factor (PlGF). |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of persistent hypertension defined by 24 hours BP measurement | Frequency of persistent hypertension defined by 24 hours BP measurement | through study completion, an average of 5 years |
| Frequency of persistent hypertension defined by office blood pressure measurement (OBPM, AOBPM) | Frequency of persistent hypertension defined by office blood pressure measurement (OBPM, AOBPM) | through study completion, an average of 5 years |
| Frequency of microalbuminuria | Frequency of microalbuminuria | through study completion, an average of 5 years |
| Frequency of damage to the retina of the eyes (retinopathy) | Frequency of damage to the retina of the eyes (retinopathy) | through study completion, an average of 5 years |
| Signs of hypertensive heart disease | Signs of hypertensive heart disease at transthoracic echocardiography determined by left ventricular hypertrophy (LVH) | up to 24 months |
| Frequency of dyslipidemia | Frequency of dyslipidemia | through study completion, an average of 5 years |
| Frequency of prediabetes/diabetes | Frequency of prediabetes/diabetes | through study completion, an average of 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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The study will take place at the Hypertension Clinic of the Medical Outpatient Department at the University Hospital Basel and the Department of Obstetrics and Gynaecology at the University Hospital Basel. Participants will be consecutively screened and recruited by the treating physicians and the Hypertension Team of the Hypertension Clinic.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thenral Socrates, Dr. med. | Contact | +41 61 328 6647 | thenral.socrates@usb.ch | |
| Thilo Burkard, Dr. med. | Contact | +41 61 328 7738 | thilo.burkard@usb.ch |
| Name | Affiliation | Role |
|---|---|---|
| Thenral Socrates, Dr. med. | Medical Outpatient Department and Hypertension Clinic, University Hospital BaselUni | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Outpatient Department and Hypertension Clinic, University Hospital Basel | Recruiting | Basel | 4031 | Switzerland |
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blood samples for biomarker
| Data collection on patient reported outcomes | Other | Data collection on patient reported outcomes (Questionnaire EQ-5D, Questionnaire for App based monitoring ) |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D003625 | Data Collection |
| D001794 | Blood Pressure |
| ID | Term |
|---|---|
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D055986 | Vital Signs |
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006439 | Hemodynamics |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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