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This study is a randomized proof-of-concept study to assess the efficacy of Virtual Reality (VR) vs standard of care in 50 adult patients in the New York Presbyterian Burn Unit. The participants who are randomized to receive the virtual reality intervention will also receive opioids, which is the standard of care and is known to be effective. Participants will be randomly assigned to two groups. The first group will receive VR during their painful procedure (e.g., wound dressing changes, physical therapy etc.) in addition to the standard of care. The other group will receive standard of care (and no VR).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Virtual Reality | Experimental | Virtual reality-enhanced distraction using a portable head mounted display during panful events (such as wound dressing changes or physical therapy sessions) in addition to standard of care. |
|
| Treatment as Usual | No Intervention | Standard of care during painful event (such as wound dressing changes or physical therapy sessions). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Virtual Reality | Other | Immersive and interactive game played through a portable head-mounted display as a distraction mechanism |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pain | Initial determination of the clinical efficacy of VR in reducing the total pain (determined by the subjective standard 0-10 pain scale) where 0 = no pain and 10 = worst pain. | Peri-procedural: 30 minutes before to two hours after the painful event. |
| Change in narcotic dose | Dose of narcotics needed peri-procedure | Peri-procedural: 30 minutes before to two hours after the painful event. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in narcotic dose | Determine if the one-time VR-distraction intervention reduces dose of analgesics for the day after the painful events and the remained of the post-procedure hospitalization | Day 1 of hospitalization to last day of hospitalization (approximately 15 days) |
| Change in anxiolytics dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Olivia Baryluk, BS | Contact | 212-821-0783 | olb4002@med.cornell.edu |
| Name | Affiliation | Role |
|---|---|---|
| JoAnn Difede, PhD | Weill Medical College of Cornell University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Weill Cornell Medicine | Recruiting | New York | New York | 10065 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41942793 | Derived | Emrich M, McAleavey AA, Wyka K, Greenway A, Houng AP, Chang PH, Zhou C, Difede J. Feasibility of Mobile Phone-Based Virtual Reality as a Non-pharmacologic Acute Procedural Pain Management Intervention in an Inpatient Burn Center. J Clin Psychol Med Settings. 2026 Jun;33(2):381-392. doi: 10.1007/s10880-026-10146-z. Epub 2026 Apr 6. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D000377 | Agnosia |
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010468 | Perceptual Disorders |
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Determine if the one-time VR-distraction intervention reduces anxiolytic dose after painful event |
| Day 1 of hospitalization to last day of hospitalization (approximately 15 days) |
| Change in Anxiety Symptoms | Determined by visual analog scales (0-100) where 0 = no anxiety and 100 = worst possible anxiety. | Peri-procedural: 30 minutes before to two hours after the painful event. |
| Change in Depressive Symptoms | Determined by visual analog scales (0-100) where 0 = no depression and 100 = worst possible depression. | Peri-procedural: 30 minutes before to two hours after the painful event. |
| D019954 | Neurobehavioral Manifestations |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |