Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients

Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients

This study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement. Secondary objectives are to determine whether this low-dose esketamine infusion will increase the stability of circulation.

Inclusion Criteria:

• All intubated adult burn patients( age>18 ), presenting to the operating room;
• Burn area> 30%.

Exclusion Criteria:

• Allergy to Esketamine or benzodiazepines
• Esketamine or ketamine use in the preceding 24 hours
• Increased intracranial pressure
• Increased intraocular pressure
• Porphyria
• Thyroid disorders
• Seizures
• Acute myocardial ischemia
• Children (patients under age 18), prisoners, pregnant or breastfeeding women, patients with psychosis, patients with developmental delay, and any condition which, in the opinion of the investigator, would prevent full participation in this study or would interfere with the evaluation of the trial endpoints.