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| ID | Type | Description | Link |
|---|---|---|---|
| H6O-MC-O016 | Other Identifier | Eli Lilly and Company |
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The main purpose of this study in healthy participants is to find out whether a heart rate monitor will accurately pick up changes in heart rate caused by 2 different medications (pseudoephedrine and metoprolol), on the background of daily activities. Participants will wear a patch heart rate and activity monitor on the chest for the entire study. The study will last about 36 days and may include up to seven visits to the study center.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Wearable Biosensor Patch Device + Propranolol | Experimental | Participants will wear the biosensor patch device followed by propranolol administered orally in one of three study periods. |
|
| Wearable Biosensor Patch Device + Pseudoephedrine | Experimental | Participants will wear the biosensor patch device followed by pseudoephedrine administered orally in one of three study periods. |
|
| Wearable Biosensor Patch Device (Alone) | Experimental | Participants will wear biosensor patch device (alone) during one of three study periods. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propranolol | Drug | Administered orally. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The mean change in heart rate (HR) | The mean change in HR | Day 1: Hour 1, Hour 4 post intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) | Eli Lilly and Company | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lilly Centre for Clinical Pharmacology | Singapore | 138623 | Singapore |
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| ID | Term |
|---|---|
| D011433 | Propranolol |
| D054199 | Pseudoephedrine |
| ID | Term |
|---|---|
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
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| Pseudoephedrine |
| Drug |
Administered orally. |
|
| Wearable Biosensor Patch Device | Device | Biosensor patch device attached to the chest and worn throughout the trial with replacement of biosensor every 7 days. |
|
| D009930 |
| Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |