Impact of Platinum-based Cancer Treatment on Endothelial Function

The Effect of Polychemotherapy on Endothelial Function Ans Vessel Age in Cancer Patients.

In this research we investigate endothelial function in cancer patients who received platinum based chemotherapy.

The goal of the study is to evaluate endothelial function in patients with platinum-based versus non-platinum-based chemotherapy.

Endothelial function was evaluated via Angioscan( the apparatus that evaluate the stiffness of vessels by pulse wave velocity) and serum levels of endothelial nitric oxide synthase (ENOS),endothelin1.

Patients with gastrointestinal, ovarian, bladder and brest cancer would be included.

Patients with malignancies were followed-up from 2 weeks to 3 month after start of chemotherapy, Medical records and hospital databases were searched for all the patients treated with different chemotherapy treatment for any kind of cancer.

Inclusion Criteria:

• Subject has solid cancer
• Subject is expected to start chemotherapy

Exclusion Criteria:

• Pregnancy and lactation
• Severe impaired kidney function
• Severe hepatic impairment
• Mental disease
• Acute myocardial infarction 28 days ago or earlier
• Acute Cerebrovascular Event 1 month ago or earlier
• Rhythm disturbance that complicate pulse wave velocity evaluation