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In this research we investigate endothelial function in cancer patients who received platinum based chemotherapy.
The goal of the study is to evaluate endothelial function in patients with platinum-based versus non-platinum-based chemotherapy.
Endothelial function was evaluated via Angioscan( the apparatus that evaluate the stiffness of vessels by pulse wave velocity) and serum levels of endothelial nitric oxide synthase (ENOS),endothelin1.
Patients with gastrointestinal, ovarian, bladder and brest cancer would be included.
Patients with malignancies were followed-up from 2 weeks to 3 month after start of chemotherapy, Medical records and hospital databases were searched for all the patients treated with different chemotherapy treatment for any kind of cancer.
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| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of blood pressure | Both systolic and diastiolic blood pressure were measured in the office in the seated position, noninvasively. | Before start of chemotherapy (1 hour after including in the trial) |
| Evaluation of flow-mediated vasodilation and pulse-wave velocity | Flow-mediated dilatation and pulse-wave velocity were measured via "Angioscan" apparatus in the seated position.The cuff inflation period of 5 min was initially decided to produce adequate hyperaemia to allow flow-mediated dilatation. The scanning period used in our trial was 1 minite before and 9 minutes after the cuff deflation. | Before start of chemotherapy (1 hour after including in the trial) |
| Evaluation of concetration of ENOS and Big Endothelin in blood sampling | Blood was collected from the cubital vein to 10.0 ml/ 6.0 ml red top tubes (without clot activator). The sample was then separated by centrifugation. The serum was frozen to -20C. | Before start of chemotherapy (1 hour after including in the trial) |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of blood pressure | Both systolic and diastiolic blood pressure was measured in the office in the seated position, noninvasively. | In range of 3 -12 weeks after start of chemotherapy (before next chepotherapy drug injection) |
| Evaluation of flow-mediated vasodilation and pulse-wave velocity |
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Inclusion Criteria:
Exclusion Criteria:
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In this study included 60 patients, that have diagnosis solid cancer of any stage and localisation.All of them is expected to start platinum based or non platinum based chemotherapy.The study proseeds in Chemotherapy department at City Hospital No.1.
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| Name | Affiliation | Role |
|---|---|---|
| Dmitry Shchekochikhin, PhD | I.M. Sechenov First Moscow State Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Olga Andreeva | Moscow | 119421 | Russia | |||
| First Moscow State Medical University. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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Blood serum
Flow-mediated dilatation and pulse-wave velocity were measured via "Angioscan" apparatus in the seated position.The cuff inflation period of 5 min was initially decided to produce adequate hyperaemia to allow flow-mediated dilatation. The scanning period used in our trial was 1 minite before and 9 minutes after the cuff deflation. |
| In range of 3 -12 weeks after start of chemotherapy (before next chepotherapy drug injection) |
| Evaluation of concetration of ENOS and Big Endothelin of blood sampling | Blood was collected from the cubital vein to 10.0 ml/ 6.0 ml red top tubes (without clot activator). The sample was then separated by centrifugation. The serum was frozen to -20C. | In range of 3 -12 weeks after start of chemotherapy (before next chepotherapy drug injection) |
| Moscow |
| Russia |