• The Impact Of Respiratory Neuromuscular Stimulation On Patients With Invasive Mechanical Ventilation

  NCT06952335

  Not yet recruitingInterventionalNot ApplicableUpdated Apr 30, 2025
• Assessment of Human Diaphragm Strength by Magnetic and Electric Stimulation After Ultrasonography Phrenic Nerve Tracking

  NCT04199273

  CompletedInterventionalNot ApplicableUpdated Sep 16, 2022
• Optimization of Non-invasive Diaphragm Activation Using Magnetic Phrenic Nerve Stimulation

  NCT04176744

  CompletedInterventionalNot ApplicableUpdated Aug 12, 2020
• Phrenic Nerve Stimulation for Reducing Ventilation Duration in Acute Cerebral Infarction: A Multicenter Randomized Controlled Trial

  NCT07133932

  Not yet recruitingInterventionalNot ApplicableUpdated Aug 21, 2025
• Repetitive Phrenic Nerve Stimulation in Critically Ill Patients Under Mechanical Ventilation

  NCT06491511

  CompletedObservationalUpdated May 25, 2025
• Volontary Inspiratory Muscles Measures Compared With Phrenic Nerves Magnetic Stimulations Measures

  NCT02078050

  TerminatedInterventionalNot ApplicableUpdated Jan 12, 2017

ClinicalTrials.gov ID

NCT04680351

Lead Sponsor

University Hospital, AngersOTHER_GOV

Overall Status

Unknown status

Study Type

Interventional

Phase

Not Applicable

Enrollment

10Estimated

Last Update Posted

Dec 23, 2020Actual

Start Date

Mar 1, 2021Estimated

Primary Completion Date

Apr 1, 2023Estimated

Completion Date

Apr 1, 2023Estimated

Official Title

Evaluation of the Hemodynamic Effects of Transvenous Phrenic Stimulation

Brief Summary

Mechanical ventilation is a cornerstone in the management of severe forms of pneumonia, acute respiratory distress syndrome. It provides essential oxygen to patients, ventilates the lungs but also has deleterious effects like any treatment, in particular by reducing cardiac output by reducing venous return. Mechanical ventilation also has effects on the diaphragm: diaphragmatic dysfunction. It is explained by a prolonged inactivity of this muscle with a reduction of muscle fibers that can settle down quickly, after only a few days of mechanical ventilation. This dysfunction results in a reduction in the latter's ability to generate intrathoracic pressure necessary for ventilation, slows the withdrawal of mechanical ventilation and lengthens the duration of stay in intensive care unit. To reduce this dysfunction, phrenic stimulation has been proposed as an alternative to remuscler the diaphragm thanks to electrodes located on a central venous catheter, also used to deliver the usual therapies in intensive care unit.

The HEMOSTIM study is interested in the effects of phrenic stimulation on regional ventilation, cardiac output and cerebral perfusion: investigator hypothesize that diaphragmatic stimulation allows an improvement of these parameters.

• Mechanical Ventilation

• phrenic stimulation

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Patient included in RESCUE 3 study, interventional arm with phrenic stimulation
• Patient or family consent

Exclusion Criteria:

• Patient not affiliated or not benefiting from a social security scheme

Primary Purpose

Diagnostic

Allocation

N/A

Interventional Model

Single Group Assignment

Masking

None (Open Label)

Lead Sponsor

University Hospital, AngersOTHER_GOV

alexandra.beurton@aphp.fr

martin.dres@aphp.fr