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This study is randomized comparative analytical prospective study that included patients with mild and moderate alopecia areata. Patients was divided into two groups Patients in the first group underwent Superficial cryotherapy using dimethyl ether and propane (DMEP) at -57C (Cryotherapy group). Patients in the second group underwent Microneedling (Microneedling group). A total of six sessions were done at 2 weeks interval. Patients were followed-up for next 3 months to evaluate the persistence of hair regrowth after therapy. Patients were assessed at baseline and during follow up using photography, Dermoscopy, SALT score and regrowth scale.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cryotherapy group | Active Comparator | Patients underwent superficial cryotherapy using dimethyl ether and propane (DMEP) at -57C very 2 weeks for maximum six sessions |
|
| Microneedling group | Active Comparator | Patients underwent microneedling 2 weeks for maximum six sessions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DMEP kit | Procedure | Superficial Cryotherapy using dimethyl ether and propane (DMEP) at -57C |
|
| Measure | Description | Time Frame |
|---|---|---|
| Regrowth Scale | 0 score (regrowth < 10%) no response
| Change in regrowth scale from baseline to 3 months follow after end of sessions |
| Measure | Description | Time Frame |
|---|---|---|
| SALT score | SALT score is the sum of the percentage of hair loss in all the abovementioned areas. For example, if the percentage hair loss in vertex, right profile, left profile, and posterior aspect is 20, 30, 40, and 50% respectively; then, SALT score = (20 × 0.4) = (30 × 0.18) + (40 × 0.18) + (50 × 0.24) = 8 + 5.4 + 7.2 + 12 = 32.6. | Change in salt score from baseline to 3 months follow after end of sessions |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zeinab A Gouda, MSc | Sohag Faculty of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag Faculty of Medicine | Sohag | 52324 | Egypt |
data will be provided upon request
Always
Request to prinicipal investigator
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| ID | Term |
|---|---|
| D000506 | Alopecia Areata |
| ID | Term |
|---|---|
| D000505 | Alopecia |
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
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Patients will be divided into two groups (randomly assigned and comparably cross matched for age and sex) Cryotherapy group (No.= 50): Superficial cryotherapy using dimethyl ether and propane (DMEP) at -57C Microneedling group (No. = 50): Microneedling
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| Dermapen | Device | Under aseptic precautions, the dermapen was moved on the alopecic patches diagonally, vertically and horizontally 4 to 5 times in each direction Pin point bleeding was taken as an end point |
|
| D017437 |
| Skin and Connective Tissue Diseases |