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| Name | Class |
|---|---|
| Kappa Bioscience | UNKNOWN |
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The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | 380 mg capsule/day micro-crystalline cellulose |
|
| Vitamin K2 | Active Comparator | 380 mg capsule/day micro-crystalline cellulose including 240ug/day Vitamin K2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin K2 | Dietary Supplement | Vitamin K2 |
| |
| Micro-crystalline cellulose |
| Measure | Description | Time Frame |
|---|---|---|
| Change in post exercise recovery of muscle strength | Muscle strength (MVC) of the knee extensor muscles will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise | Change from baseline to 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in pain free range of motion during knee extension exercise | The range of motion which is pain free will be measured during knee extension using a goniometer before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise | Change from baseline to 12 weeks |
| Change in post exercise recovery of functional abilities |
| Measure | Description | Time Frame |
|---|---|---|
| Change in lean mass | Change in lean mass | Change from baseline to 12 weeks |
| Change in blood glucose | Change in blood glucose | Change from baseline to 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Glasgow | Glasgow | G12 8TA | United Kingdom | |||
| Stuart Robert Gray |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36539791 | Derived | Lithgow H, Johnston L, Ho FK, Celis-Morales C, Cobley J, Raastad T, Hunter AM, Lees JS, Mark PB, Quinn TJ, Gray SR. Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults-the TAKEOVER study. Trials. 2022 Dec 20;23(1):1026. doi: 10.1186/s13063-022-06937-y. |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D024482 | Vitamin K 2 |
| ID | Term |
|---|---|
| D014812 | Vitamin K |
| D009285 | Naphthoquinones |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
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| Dietary Supplement |
Micro-crystalline cellulose |
|
Time to complete 5 chair rises will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise |
| Change from baseline to 12 weeks |
| Change in post exercise recovery of sEMG activity | Quadriceps muscle sEMG will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise | Change from baseline to 12 weeks |
| Change in post exercise interleukin-6 | Circulating interleukin-6 will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise | Change from baseline to 12 weeks |
| Change in post exercise peroxiredoxin 3 redox state | Circulating peroxiredoxin 3 redox state will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise | Change from baseline to 12 weeks |
| Change in vitamin K levels | Vitamin K will be measured in baseline and 12 week samples | Change from baseline to 12 weeks |
| Change in Carboxylated Osteocalcin levels | Carboxylated Osteocalcin will be measured in baseline and 12 week samples | Change from baseline to 12 weeks |
| Change in uncarboxylated Osteocalcin levels | uncarboxylated Osteocalcin will be measured in baseline and 12 week samples | Change from baseline to 12 weeks |
| Change in carboxylated matrix gla-protein levels | carboxylated matrix gla-protein will be measured in baseline and 12 week samples | Change from baseline to 12 weeks |
| Change in dephosphorylated-uncarboxylated matrix gla-protein levels | dephosphorylated-uncarboxylated matrix gla-protein will be measured in baseline and 12 week samples | Change from baseline to 12 weeks |
| Change in post exercise F2 isoprostanes | Circulating F2 isoprostanes will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise | Change from baseline to 12 weeks |
| Change in blood lipids | Change in blood lipids | Change from baseline to 12 weeks |
| Change in plasma insulin | Change in plasma insulin | Change from baseline to 12 weeks |
| Change in fat mass | Change in fat mass | Change from baseline to 12 weeks |
| Change in muscle thickness | Change in muscle thickness | Change from baseline to 12 weeks |
| Change in exercise substrate utilisation | Energy expenditure, carbodhydrate and fat oxidation during treadmill walking | Change from baseline to 12 weeks |
| Glasgow |
| United Kingdom |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D010836 | Phytol |
| D004224 | Diterpenes |
| D013729 | Terpenes |
| D011809 | Quinones |
| D011083 | Polycyclic Compounds |