To determine whether there is a role for the selective serotonin reuptake inhibitors, fluoxetine, as therapy in the treatment of refractory primary monosymptomatic nocturnal enuresis in children , and whether there are side effects involved.

Inclusion Criteria:

• Primary Monosymptomatic nocturnal enuresis
• Failed treatment with desmopressin.
• The enuresis alarm had either been tried without effect, or deemed unfeasible because of the family situation.
• All patients had either tried and failed combination therapy with anticholinergics or, because of contraindications, been unable to receive such therapy.
• Severe enuresis with at least seven wet nights out of 14

Exclusion Criteria:

• Underlying renal, urologic, neurologic, endocrinologic, or cardiac conditions
• Depression
• Severe psychiatric diseases
• Untreated constipation

Open Label