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In order to understand the life history of the breast milk flora, explore its composition, source of strains, and ability to colonize the baby's intestinal environment, to find out strains with the potential of probiotics in breast milk
This is a double-blind and randomized study. After being discharged from the hospital, the subject was notified to consume the Babyguard breast milk probiotic daily for 1 month, and observe whether the mother's stool, breast milk and baby stool samples can find the same strain. The clinical diagnosis items of the bacterial strains of mother feces, breast milk and baby feces samples are evaluated by the doctor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | consume 1 sachet per day for 1 months |
|
| Babyguard® Breast Milk Probiotics | Experimental | consume 1 sachet per day for 1 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | consume 1 sachet per day for 1 months |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Microflora of mother's feces | Collect mother's feces for bacterial analysis.The mother's feces use Qiagen stool mini kit to extract DNA, and then use the intestinal bacteria primers to detect the presence of intestinal bacteria in the feces. | 4-6 weeks after the baby is born |
| Group. B Streptococcus (GBS) screening | Use sterile cotton sticks for vaginal samples, and then perform Group. B Streptococcus (GBS) screening | 35-37 weeks of pregnancy |
| The microflora of maternal blood | Use venous blood to collect 20 ml of mother's blood for bacterial analysis.The mother's blood uses Qiagen DNA isolation mini kit to extract DNA, and then uses intestinal bacteria primers to detect the presence of intestinal bacteria in the blood | 4-6 weeks after the baby is born |
| Metabolic analysis of maternal urine | Collect 10 ml of mother's urine for intestinal dysbiosis analysis. Use Qiagen DNA isolation mini kit to extract DNA from the mother's urine, and then use the intestinal bacteria primer to detect the presence of intestinal bacteria in the urine. | 4-6 weeks after the baby is born |
| Bacteria analysis of breast milk | Collect 10 ml of breast milk for bacterial phase analysis.Use Qiagen DNA isolation mini kit to extract DNA from breast milk, and then use intestinal bacteria primers to detect whether the breast milk contains intestinal bacteria. | 4-6 weeks after the baby is born |
| Bacteria analysis of infant feces | Collect baby feces for bacterial phase analysis.Use Baby feces use Qiagen stool mini kit to extract DNA, and then use intestinal bacteria primers to detect the presence of intestinal bacteria in the feces. |
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Inclusion Criteria:
Exclusion Criteria:
Those who are 20 years old and pregnant
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| Name | Affiliation | Role |
|---|---|---|
| Ming Shiang Wu, Doctor | National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Taipei | Zhongzheng District | 100225 | Taiwan |
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| Babyguard® Breast Milk Probiotics |
| Dietary Supplement |
consume 1 sachet per day for 1 months |
|
| 4-6 weeks after the baby is born |