Effects of 4 Weeks Supplementation With L-Citrulline and Glutathione on Arterial Function and Cardiovascular Responses in Postmenopausal Healthy Women: A Pilot Study
Effects of 4 Weeks Supplementation With L-Citrulline and Glutathione on Arterial Function and Cardiovascular Responses in Postmenopausal Healthy Women: A Pilot Study
Examining the effects of 4 weeks of Citrulline alone or in combination with glutathione on the arterial function of postmenopausal women.
L-Citrulline is a non-protein amino acid and an efficient precursor of L-arginine, the substrate for endothelial nitric oxide synthesis. Glutathione is a tripeptide with antioxidant effects. Postmenopausal women will ingest 6g/d of L-Citrulline or 2g of L-Citrulline plus 200mg/d of glutathione or placebo (maltodextrin) for 4 weeks with vascular function testing prior to and after the intervention.
Inclusion Criteria:
Exclusion Criteria:
Current or prior use of tobacco products, e-cigarettes or other inhaled substance.
Use of medications and/or any supplements that may affect outcome variables (such as arginine-containing supplements, nitroglycerin, statin drugs, but not limited to those.)
Taking hormone replacement therapy during the 3 months before the study.
More than a moderate intake of alcohol (>7 drink per week).
Cardiovascular diseases, diabetes and other metabolic or chronic diseases.
Musculoskeletal disorders that will prevent exercise performance.
Currently taking more than one vasoactive drug for blood pressure control.