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| Name | Class |
|---|---|
| Kyowa Hakko Bio Co., Ltd. | INDUSTRY |
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Examining the effects of 4 weeks of Citrulline alone or in combination with glutathione on the arterial function of postmenopausal women.
L-Citrulline is a non-protein amino acid and an efficient precursor of L-arginine, the substrate for endothelial nitric oxide synthesis. Glutathione is a tripeptide with antioxidant effects. Postmenopausal women will ingest 6g/d of L-Citrulline or 2g of L-Citrulline plus 200mg/d of glutathione or placebo (maltodextrin) for 4 weeks with vascular function testing prior to and after the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L-Citrulline + Glutathione | Experimental | Citrulline: 2 grams/day, Glutathione: 200mg/day for 4 weeks |
|
| L-Citrulline | Experimental | Citrulline: 6 grams/day |
|
| Placebo | Placebo Comparator | Maltodextrin: 6 grams/day |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-Citrulline | Dietary Supplement | Four weeks of oral L-Citrulline (2 grams/day) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in endothelial function | Endothelial function will be measured before and after the intervention using brachial artery flow mediated dilation at rest, blood flow measured in the brachial artery during handgrip exercise, and blood flow in the common femoral artery during passive leg movement. All measurements performed using doppler ultrasound. | 4 weeks |
| Change in arterial stiffness | Arterial stiffness will be assessed through measurement of pulse-wave velocity of the carotid-femoral, carotid radial, carotid-ankle and femoral ankle arterial segments before and after the 4 week interventions. | 4 weeks |
| Blood pressure control during the cold pressor test | Blood pressure will be measured during the cold pressor test before and after the 4 weeks. | 4 weeks |
| L-Arginine bioavailability | Plasma levels of arginine will be measured before and after the 4 week intervention. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| cardiovascular hemodynamics using pulse wave analysis during the cold pressor test | arterial tonometry will be measured during the cold pressor test before and after the 4 week intervention. | 4 weeks |
| body composition |
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Inclusion Criteria:
Exclusion Criteria:
Current or prior use of tobacco products, e-cigarettes or other inhaled substance.
Use of medications and/or any supplements that may affect outcome variables (such as arginine-containing supplements, nitroglycerin, statin drugs, but not limited to those.)
Taking hormone replacement therapy during the 3 months before the study.
More than a moderate intake of alcohol (>7 drink per week).
Cardiovascular diseases, diabetes and other metabolic or chronic diseases.
Musculoskeletal disorders that will prevent exercise performance.
Currently taking more than one vasoactive drug for blood pressure control.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| TTU Kinesiology and Sport Management Building | Lubbock | Texas | 79409 | United States |
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| ID | Term |
|---|---|
| D002956 | Citrulline |
| D005978 | Glutathione |
| ID | Term |
|---|---|
| D000599 | Amino Acids, Diamino |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
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Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator)
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Randomized, placebo-controlled, double-blind, parallel-groups study.
| L-Citrulline | Dietary Supplement | Four weeks of oral L-Citrulline (6 grams/day) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night. |
|
| Placebo | Dietary Supplement | Four weeks of oral placebo (6 grams/day maltodextrin) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night. |
|
| Glutathione | Dietary Supplement | Four weeks of Glutathione (200mg/day) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night. |
|
We will determine whether L-citrulline + glutathione changes body composition more than L-citrulline or placebo.
| 4 weeks |
| Muscle Strength | Leg Extension strength will be measured before and after the 4 weeks. | 4 weeks |
| L-Citrulline levels | Plasma levels of L-Citrulline will be measured before and after the 4 weeks. | 4 weeks |
| Glutathione peroxidase levels | Blood levels of glutathione peroxidase will be measured before and after the 4 weeks | 4 weeks |
| Malondialdehyde | blood levels of malondialdehyde will be measured before and after the 4 weeks | 4 weeks |
| L-Ornithine levels | plasma levels of L-ornithine will be measured before and after the 4 weeks | 4 weeks |
| D010455 |
| Peptides |