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Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization.
Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactate Dehydrogenase | Diagnostic Test | All the patients that arrived at the hospital with symptoms of mesenteric ischemia, had a registered lactate dehydrogenase. We compared the value with the patient's outcomes. |
| Measure | Description | Time Frame |
|---|---|---|
| Serum Lactate in mmol/l | 30 days | |
| Bowel necrosis length in cm | 30 days | |
| Percentage of patients that died between 30 postsurgical days, % | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Cut value of lactate levels as a predictor of mortality, in mmol/l | A receiver operating characteristics curve | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
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Seventy-four cases were identified that met the study's criteria. The patients' average age was 73.5 (SD, 10.7) years, and 44 (60%) were men. The mean body mass index was 25 (SD, 2.9) kg/m2. Fifteen (20%) of the patients presented non-occlusive acute mesenteric ischemia.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Andres Isaza Restrepo | Bogotá | Cundinamarca | 111221 | Colombia |
We don't plan to share de IPD.
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| ID | Term |
|---|---|
| D065666 | Mesenteric Ischemia |
| ID | Term |
|---|---|
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D010532 | Peritoneal Diseases |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |