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While absolute quantification in 18F-FDG PET (Positon Emission Tomography) is widely used in clinical routine, absolute quantification in SPECT (Single Photon Emission Computed Tomography) is under development and its clinical interest remains to be demonstrated. Recent studies carried out on bone scan recordings show the potential interest of quantification indexes such as SUV (Standard Uptake Value).
In oncology, bone scan studies have reported significantly higher SUV values for secondary bone lesions compared with benign osteoarticular lesions , and some have even defined an SUVmax threshold value that points to prostatic bone metastases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient for SPECT/CT scan | Patients referred for SPECT/CT scan of the spine as part of a vertebroplasty workup and selected retrospectively. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SPECT CT | Device | SPECT/CT scan of the spine as part of a vertebroplasty |
|
| Measure | Description | Time Frame |
|---|---|---|
| To validate the absolute bone scan quantification in a retrospectively selected patient population | Analysis of SUV variation on at least 2 bone scans: Variation of the SUV over time on scans of patients with spinal fractures | After 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| To calibrate the tomographic images from the gamma camera | Calibrate the tomographic images from the gamma camera to obtain a volume activity in Bq/mLand densities | 1 day |
| To evaluate the attenuation correction on phantoms of different density |
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Inclusion Criteria:
Patients with recent vertebral fractures:
Exclusion Criteria:
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Patients referred for SPECT/CT scan of the spine as part of a vertebroplasty workup and selected retrospectively.
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| Name | Affiliation | Role |
|---|---|---|
| BALHOUL Achraf, MD | CHRU of Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nancy - Hôpital Brabois | Vandœuvre-lès-Nancy | 54500 | France | |||
| Chru Nancy |
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| ID | Term |
|---|---|
| D000072098 | Single Photon Emission Computed Tomography Computed Tomography |
| ID | Term |
|---|---|
| D015899 | Tomography, Emission-Computed, Single-Photon |
| D014055 | Tomography, Emission-Computed |
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
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SUV absolute quantitation index (SUVmax, SUVpeak, SUVmean).
| 1 day |
| To evaluate absolute quantification on phantoms | Evaluate absolute quantification on phantoms with objects of different volumes | 1 day |
| Vandœuvre-lès-Nancy |
| 54511 |
| France |
| CHRU of Nancy | Vandœuvre-lès-Nancy | 54511 | France |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014057 | Tomography, X-Ray Computed |
| D064847 | Multimodal Imaging |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D011877 | Radionuclide Imaging |
| D014054 | Tomography |
| D003947 | Diagnostic Techniques, Radioisotope |