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Deficient alveolar mandibular ridge corrected distraction osteogenesis to facilitate dental implant placement. Patients grouped into 2 groups: one group received Cissus quadrangularis during the consolidation period, and the other group received placebo.
OPGs were taken immediately after distractor placement, at end of activation period, at 1st,2nd month of consolidation period, and at end of consolidation period. Change in bone height was evaluated immediately after distractor placement, at end of activation and end of consolidation periods.
CBCT were taken immediately after implant installation, and 6 months later to evaluate change bone density and marginal bone level about the dental implant.
histological evaluation was done by biopsy obtained, by trephine bur, from implant site during its preparation. The bone biopsy fixed in 4% formalin solution for 7 days, rinsed in water, and dehydrated in sequent phases of ethanol (70, 80, 90, and 100%) and then specimens were stained by hematoxylin- eosin for microscopic evaluation.
Radiographic evaluation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Placebo Comparator | Placebo was given to ten patients during consolidation period ( 2 capsule daily for 6 months during consolidation period) |
|
| Group 2 | Experimental | Cissus quadrangularis in form of capsules given to ten patients ( 2 capsule daily for 6 months during consolidation period) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cissus Quadrangularis | Drug | Drug with osteogenic potential given to the patients after consolidation period. dose was two capsules once /day with meals for 6 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bone gain after distraction | Increase in bone height after distraction | immediately at end of distractor activation |
| Relapse after distraction | Relapse evaluated on panorama | 3 months from beginning of consolidation period |
| Crestal bone loss around dental implant | By using cone beam CT, crestal bone level around implant evaluated by measuring a distance from implant apex to a point on dental implant where bone contacts the dental implant mesially and distally. then average of bone loss round each implant was obtained. | 6 months from implant placement |
| Bone density around dental implant | By using cone beam CT, bone density assessed around dental implant at crestal, middle, and apical portions then average was obtained | 6 months from implant placement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Altaweel | Al-Alharby university | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of dental medicine | Cairo | Nasr City | 11651 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34607598 | Derived | Altaweel AA, Baiomy AABA, Shoshan HS, Abbas H, Abdel-Hafiz AA, Gaber AE, Zewail AA, Elshiekh MAM. Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction. BMC Oral Health. 2021 Oct 4;21(1):491. doi: 10.1186/s12903-021-01847-y. |
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| ID | Term |
|---|---|
| D000070631 | Diastasis, Bone |
| ID | Term |
|---|---|
| D004204 | Joint Dislocations |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D014947 | Wounds and Injuries |
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