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This project is designed as a prospective, randomized, open, controlled clinical trial. For the first time, acupuncture was applied to the treatment of dry ocular neuropathic pain. Its mechanism was discussed by comparing the efficacy between acupuncture and artificial tears.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Artificial tears | Experimental | Artificial tears |
|
| Acupuncture | Active Comparator | Acupuncture |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sodium hyaluronate eye drops | Drug | eye drops, three times a day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analogue Score | Ask the patient to mark the corresponding position on the ruler that can represent the pain or discomfort during the onset | The treatment period for each enrolled subject is one month |
| Measure | Description | Time Frame |
|---|---|---|
| OSDI | OSDI consists of 12 scoring items, divided into three parts: severity of symptoms, impact of symptoms on daily life, and impact of environment on symptoms. | The treatment period for each enrolled subject is one month |
| TBUT |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Beijing | Beijing Municipality | 100191 | China | ||
| Peking University Third Hospital |
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| D010146 | Pain |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D065346 | Lubricant Eye Drops |
| D015670 | Acupuncture Therapy |
| ID | Term |
|---|---|
| D009883 | Ophthalmic Solutions |
| D019999 | Pharmaceutical Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| acupuncture | Other | three times a week |
|
Drop 1 drop of 0.3% sodium fluorescein eye solution into the subject's conjunctival sac, dry it with a sterile cotton swab, and ask him to blink gently to make the fluorescein sodium evenly distributed. Observe the subject from the last time with a slit lamp cobalt blue light. The time from blinking to the first dark spot on the corneal surface, record three times and take the average
| The treatment period for each enrolled subject is one month |
| SIt | Fold one end of the special 5mm×35mm filter paper (Tianjin Jingming) for tears by 5mm, and gently place it on the middle and outer 1/3 of the subject's lower eyelid conjunctival sac, and the other end will droop naturally. Ask the subject to gently close their eyes for 5 minutes After measuring the length of the filter paper wetted by tears | The treatment period for each enrolled subject is one month |
| CFS score | Divide the cornea into 5 quadrants (central + nose/temporal/upper/lower), each quadrant has a staining score of 0 to 3 points, and it is specified that no staining is 0 points, and 30 spots are stained as 1 point, and there is flaky staining and fusion 3 points for filament formation, 2 points between the two, the sum of 5 quadrants is the score of the entire cornea, and the CFS score of the entire cornea is 0-15 points. | The treatment period for each enrolled subject is one month |
| Density and curvature of corneal subbasal nerve | Collect corneal subbasal nerve images, 2 images each in the upper, lower, arm, temporal and central areas. Use deep learning methods to analyze nerve density and curvature | The treatment period for each enrolled subject is one month |
| Tear pain factor content | With the aid of a slit lamp, a capillary pipette was used to draw 5 μl tears/eye at the middle and outer edges of the lower eyelid 2/3 of the tear river, and placed in a low protein adhesion EP tube (containing 5 μl 1% BSA) and stored at -80°C. ELISA analyzes the protein levels of PGE2, substance P and NGF in tear fluid. | The treatment period for each enrolled subject is one month |
| Beijing |
| 100191 |
| China |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D045506 |
| Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D054327 | Lubricants |
| D020313 | Specialty Uses of Chemicals |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |