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To establish a follow-up cohort of antiretroviral therapy(ART) for patients with HIV/AIDS, to observe the ART efficacy and adverse reactions, complications in the process of ART, as well as mortality and causes of death, so as to provide basis for further improving ART efficacy and quality of life of the patients.
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| Measure | Description | Time Frame |
|---|---|---|
| The rate of virological suppression after antiretroviral therapy. | After ART, HIV RNA level in plasma were quantified every year. The rate of HIV-RNA<400 copies/ml will be used to evaluate the efficacy of ART and the variation tendency of the rate of virological suppression will be described. | Year 10 |
| Measure | Description | Time Frame |
|---|---|---|
| The CD4+T cell counts after ART. | The CD4+T cell count in plasma were detected every 3 months. The variation tendency of CD4+Tcell count will be described. | Year 10 |
| All-cause mortality among HIV/AIDS after ART. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with HIV/AIDS who are willing to receive antiretroviral therapy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Linghua Li, MD,PhD | Contact | llheliza@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Ling-Hua Li, doctor | Guangzhou Eighth People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou Eighth People's Hospital | Recruiting | Guangzhou | Guangdong | 510060 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39654313 | Derived | Lin W, He Y, Gu F, Hu F, Yu H, Li H, Liu C, Tang X, Cai W, Li L. Hepatic Flare Following Effective Antiretroviral Therapy Is Associated With HBsAg Seroclearance in HBV/HIV-1 Co-Infection. J Med Virol. 2024 Dec;96(12):e70114. doi: 10.1002/jmv.70114. |
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| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000163 | Acquired Immunodeficiency Syndrome |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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During the study, the blood sample of patients should be preserved to detect the HIV RNA load , other co-infected microbes and drug toxicity.
Describe the all-cause mortality among HIV/AIDS after ART and analyze the trend.
| Year 10 |
| The incidence of adverse reactions after ART. | In order to assess the adverse reactions after ART, the clinical symptoms were recorded, such as respiratory symptoms, digestive system symptoms, nervous system symptoms, and mental symptoms, etc. And cytological and biochemical indexes were detected such as blood routine, liver function, renal function, blood lipid, blood glucose, urine routine, etc. Calculate the incidence of adverse reactions after ART for 10 years. | Year 10 |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D012897 | Slow Virus Diseases |