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To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy. In patients with inflammatory rheumatic disorders requiring prolonged glucocorticoid therapy, such tool could be useful to adapt first-line treatment decisions (in daily practice and in future clinical trials). The main objective of the study is to identify routine clinical, biological and DXA baseline characteristics predictive of the occurrence of clinically relevant complications of glucocorticoid therapy at 1 year, in order to propose a predictive score.
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| Measure | Description | Time Frame |
|---|---|---|
| Clinically relevant complication of glucocorticoid therapy | The occurrence of one or more clinically relevant complication of glucocorticoid therapy during the first year of treatment, according to the Glucocorticoid Toxicity Index (items and specific list). | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life assessed through SF-36 | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients usually treated with prolonged glucocorticoid therapy in the field of rheumatology.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU d'Angers | Angers | 49933 | France | |||
| CHRU de Brest |
All collected data that underlie results in a publication
Data will be available beginning three years and ending five years following the publication
Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.
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| Brest |
| 29609 |
| France |
| CHD Vendée | La Roche-sur-Yon | 85925 | France |
| CH Le Mans | Le Mans | 72000 | France |
| CH des Pays de Morlaix | Morlaix | 29672 | France |
| CHU de Nantes - Service de Médecine interne | Nantes | 44093 | France |
| CHU de Nantes - Service de Rhumatologie | Nantes | 44093 | France |
| CHR d'Orléans | Orléans | 45067 | France |
| <CHU de Poitiers | Poitiers | France |
| CHIC Quimper | Quimper | 29000 | France |
| Clinique St Exupéry | Toulouse | France |
| CHU de Tours | Tours | 37044 | France |
| ID | Term |
|---|---|
| D012213 | Rheumatic Fever |
| D011111 | Polymyalgia Rheumatica |
| D013700 | Giant Cell Arteritis |
| D009220 | Myositis |
| D056648 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis |
| ID | Term |
|---|---|
| D013290 | Streptococcal Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D009135 | Muscular Diseases |
| D020293 | Vasculitis, Central Nervous System |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001167 | Arteritis |
| D014657 | Vasculitis |
| D017445 | Skin Diseases, Vascular |
| D012871 | Skin Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D009468 | Neuromuscular Diseases |
| D056647 | Systemic Vasculitis |
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