Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| CPP-CS 001/2015 | Other Identifier | CPP Nord Ouest 1 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF. Although NIV provided better oxygenation than HFNC, the effect on lung volumes could explain the potentially deleterious effect of NIV in hypoxemic ARF, reinforcing the recently developed concept of patient self-inflicted lung injury.
Background: High-flow nasal cannula (HFNC) oxygen therapy has recently shown clinical benefits in hypoxemic acute respiratory failure (ARF) patients, while the interest of non-invasive ventilation (NIV) remains debated. The primary endpoint was to compare alveolar recruitment using global end-expiratory electrical lung impedance (EELI) between HFNC and NIV. Secondary endpoints compared regional EELI, lung volumes (global and regional tidal volume variation (TV)), respiratory parameters, hemodynamic tolerance, dyspnea and patient comfort between HFNC and NIV, relative to face mask (FM).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NIV/HFNC | patients receiving non-invasive ventilation than high flow nasal canulae oxygen therapy |
| |
| HFNC/NIV | patients receiving high flow nasal canulae oxygen therapy than non-invasive ventilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non invasive ventilation and high flow nasal canulae oxygen therapy | Device | patients with hypoxemic acute respiratory failure received alternatively non invasive ventilation and high flow nasal canulae oxygen therapy |
| Measure | Description | Time Frame |
|---|---|---|
| global EELI | measurement of global end respiratory lung impedance with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic |
| Measure | Description | Time Frame |
|---|---|---|
| ROI EELI | measurement of regional of interest (ROI) end respiratory lung impedance with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic |
| global TV |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Adults referred in ICU
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Christophe GIRAULT, MD | Medical Intensive Care Department, Rouen University Hospital, F-76000 Rouen, France | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de ROUEN | Rouen | 76031 | France |
all collected IPD
from the first patient enrollment ( 02/22/2016) to publication
Excel database was shared with biostatisticians for statistical analysis
Not provided
Not provided
Not provided
Not provided
Not provided
measurement of global tidal variation (TV) with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit |
| after 5 minutes of stable breathing with the oxygenation technic |
| ROI TV | measurement of regional tidal variation with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D063087 | Noninvasive Ventilation |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
Not provided
Not provided