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Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointestinal bleeding.
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Death caused by any events during hospitalizations. | An average of 1-6 weeks, from admission to discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Failure to control bleeding within 5 days | Failure is defined as death or need to change therapy defined by one of the following criteria within 5 days: 1) Fresh hematemesis or nasogastric aspiration of ≥100 ml of fresh blood ≥2 h after the start of a specific drug treatment or therapeutic endoscopy; 2) Development of hypovolaemic shock; 3) 3g drop in hemoglobin (9% drop of hematocrit) within any 24 hours period if no transfusion is administered. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with liver cirrhosis and acute gastrointestinal bleeding
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xingshun Qi, Dr. | Contact | 18909881019 | xingshunqi@126.com | |
| Zhaohui Bai, Dr. | Contact | 18524451863 | bai_zhao_hui@foxmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Wright Center for Graduate Medical Education, 501 S. Washington Avenue | Not yet recruiting | Scranton | Pennsylvania | 18503 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31512140 | Result | Bai Z, Li B, Lin S, Liu B, Li Y, Zhu Q, Wu Y, Yang Y, Tang S, Meng F, Chen Y, Yuan S, Shao L, Qi X. Development and Validation of CAGIB Score for Evaluating the Prognosis of Cirrhosis with Acute Gastrointestinal Bleeding: A Retrospective Multicenter Study. Adv Ther. 2019 Nov;36(11):3211-3220. doi: 10.1007/s12325-019-01083-5. Epub 2019 Sep 11. | |
| 42216795 |
| Label | URL |
|---|---|
| Related Info | View source |
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| 5 days |
| São Paulo State University (UNESP), Botucatu Medical School | Recruiting | São Paulo | São Paulo | Brazil |
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| Beijing Youan Hospital, Capital Medical University | Recruiting | Beijing | Beijing Municipality | China |
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| The Seventh Medical Center of Chinese PLA General Hospital | Not yet recruiting | Beijing | Beijing Municipality | China |
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| First Affiliated Hospital of Fujian Medical University | Recruiting | Fuzhou | Fujian | China |
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| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | China |
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| First Affiliated Hospital of Nanchang University | Recruiting | Nanchang | Jiangxi | China |
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| The Six People's Hospital of Dalian | Recruiting | Dalian | Liaoning | China |
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| Air Force Hospital of Northern Theater Command | Recruiting | Shenyang | Liaoning | China |
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| General Hospital of Northern Theater Command | Recruiting | Shenyang | Liaoning | China |
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| The First Hospital of China Medical University | Recruiting | Shenyang | Liaoning | China |
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| The Six People's Hospital of Shenyang | Recruiting | Shenyang | Liaoning | China |
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| Tangdu Hospital, Fourth Military Medical University, | Recruiting | Xi'an | Shaanxi | China |
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| The First Affiliated Hospital of Xi'an Jiao Tong University | Recruiting | Xi'an | Shaanxi | China |
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| The Second Affiliated Hospital of Xi'an Jiao Tong University | Recruiting | Xi'an | Shaanxi | China |
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| Xi'an Central Hospital | Recruiting | Xi'an | Shaanxi | China |
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| Shandong Provincial Hospital | Recruiting | Jinan | Shandong | China |
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| Cathay General Hospital, Fu-Jen Catholic University School of Medicine | Not yet recruiting | Taibei | Taiwan | China |
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| Charité University Medical Center | Recruiting | Berlin | State of Berlin | Germany |
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| Ernakulam Medical Center | Not yet recruiting | Kochi | Kochi | India |
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| Azienda di Rilievo Nazionale ad Alta Specializzazione Civico-Di Cristina-Benfratelli | Recruiting | Palermo | Palermo | Italy |
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| National Autonomous University of Mexico | Recruiting | Mexico City | Mexico City | Mexico |
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| Bezmialem Vakif University | Recruiting | Istanbul | Istanbul | Turkey (Türkiye) |
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| Marcondes MB, Moreno CF, Suzuki CMP, Rodrigues MAG, Moreira A, Qi X, Romeiro FG. Impact of Cirrhosis Etiology and Intensive Care Accessibility on Upper Gastrointestinal Bleeding: A Prospective Observational Study. Can J Gastroenterol Hepatol. 2026;2026(1):e1409025. doi: 10.1155/cjgh/1409025. |
| 41273618 | Derived | Zhang S, Sun M, Yuan S, Lin S, Romeiro FG, He Y, Zhu Q, Ma D, Li Y, Philips CA, Liu X, Mendez-Sanchez N, Shao L, Wu Y, Basaranoglu M, Pinyopornpanish K, Chen Y, Mancuso A, Yang L, Tacke F, Li B, Liu L, Ji F, Qi X. Identifying Low-Risk Patients with Cirrhosis and Acute Gastrointestinal Bleeding That May Not Require Urgent Endoscopy. Adv Ther. 2026 Jan;43(1):288-303. doi: 10.1007/s12325-025-03395-1. Epub 2025 Nov 22. |
| 40745090 | Derived | Bai Z, Lin S, Sun M, Yuan S, Marcondes MB, Ma D, Zhu Q, Li Y, He Y, Philips CA, Liu X, Pinyopornpanish K, Shao L, Mendez-Sanchez N, Basaranoglu M, Wu Y, Chen Y, Yang L, Mancuso A, Tacke F, Li B, Liu L, Ji F, Qi X. Machine learning based CAGIB score predicts in-hospital mortality of cirrhotic patients with acute gastrointestinal bleeding. NPJ Digit Med. 2025 Jul 31;8(1):489. doi: 10.1038/s41746-025-01883-w. |
| ID | Term |
|---|---|
| D006471 | Gastrointestinal Hemorrhage |
| ID | Term |
|---|---|
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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