To explore the correlation between gene mutations of metastatic colorectal cancer and TCM syndrome types based on Second-generation sequencing technology.

Inclusion Criteria:

1. A clear pathological diagnosis is a patient with colorectal cancer;
2. Have complete TNM staging information;
3. There is a clear diagnosis of the location and time of metastasis;
4. Age ≥18 years old, ≤80 years old, male or female;
5. There is a clear time for the first treatment with Chinese medicine;
6. Patients who can receive long-term follow-up. -

Exclusion Criteria:

1. Patients with colorectal cancer diagnosed pathologically as adenosquamous carcinoma, squamous cell carcinoma, carcinoid, small cell carcinoma, malignant lymphoma, etc.;
2. Patients with double cancer, multiple or metastatic colorectal cancer;
3. Combined with severe acute and chronic diseases that may affect treatment and prognosis, such as myocardial infarction, stroke, severe renal insufficiency and mental illness;-