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A higher prevalence of thyroid disease has been associated with chronic kidney disease (CKD), and subclinical hypothyroidism seems to be the most common dysfunction. The aim is to evaluate thyroid function and autoimmunity in patients with CKD stages 3, 4 and 5. Cross-sectional study to be carried out on patients with stages 3 and 4 in a Nephrology outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb) levels.
Cross-sectional study to be carried out on patients with stages 3, 4 and 5 in a Nephrology outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb) levels. Free Thyroxine (FT4) will be measured by liquid chromatography tandem mass spectrometry and electrochemiluminescence immunoassay in order to compare methods in this population.
The glomerular filtration rate was estimated (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI), and the CKD stages were defined according to the Kidney Disease Improving Global Outcomes directives (KDIGO).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chonic kidney disease stages 3, 4 and 5 | Patients with stage chronic kidney disease stages 3, 4 and 5. CKD stages were defined according to the Kidney Disease Improving Global Outcomes directives (KDIGO): a) stage 3A: eGFR 45 and 59 ml/min/1.73m2; b) stage 3B: eGFR between 30 and 44 ml/min/1.73m2; c) stage 4: eGFR between 15 and 29 ml/min/1.73 m2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thyroid function | Diagnostic Test | laboratorial thyroid tests |
|
| Measure | Description | Time Frame |
|---|---|---|
| Free thyroxine (FT4) levels in chronic kidney disease | Free thyroxine levels through two different methods | through study completion, an average of 3 years |
| TSH levels in chronic kidney disease | TSH levels | through study completion, an average of 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of thyroid antibodies in chronic kidney disease | antithyroperoxidase and antitireoglobulin antibodies | through study completion, an average of 3 years |
| Free triiodothyronine (FT3) levels in chronic kidney disease |
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Inclusion Criteria:Patients over 18 years old with CKD stages 3 and 4 were included in the study.
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Exclusion Criteria: 1) acute systemic inflammatory disease; 2) pituitary disease in the past or present; 3) regular treatment with amiodarone, lithium, interferon, immunosuppressive drugs and glucocorticoids; 4) previously diagnosed hypothyroidism and undergoing levothyroxine replacement.
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Chronic kidney disease patients followed in a Nephrology outpatient clinic
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ana Beatriz Winter Tavares | Petrópolis | Rio de Janeiro | 25665-442 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27428519 | Background | Rhee CM. The interaction between thyroid and kidney disease: an overview of the evidence. Curr Opin Endocrinol Diabetes Obes. 2016 Oct;23(5):407-15. doi: 10.1097/MED.0000000000000275. | |
| 22021708 | Background | Mariani LH, Berns JS. The renal manifestations of thyroid disease. J Am Soc Nephrol. 2012 Jan;23(1):22-6. doi: 10.1681/ASN.2010070766. Epub 2011 Oct 21. |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D013960 | Thyroid Function Tests |
| ID | Term |
|---|---|
| D003940 | Diagnostic Techniques, Endocrine |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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T3 levels
| through study completion, an average of 3 years |
| 24735423 | Background | Meuwese CL, Gussekloo J, de Craen AJ, Dekker FW, den Elzen WP. Thyroid status and renal function in older persons in the general population. J Clin Endocrinol Metab. 2014 Aug;99(8):2689-96. doi: 10.1210/jc.2013-3778. Epub 2014 Apr 15. |
| 40615656 | Derived | Scandelai KS, Vianna PDBFA, Sanches JPB, Bregman R, Tavares ABW. Correlation between thyroid function and proteinuria in patients with chronic kidney disease stages 3 and 4. Int Urol Nephrol. 2025 Dec;57(12):4309-4314. doi: 10.1007/s11255-025-04646-4. Epub 2025 Jul 5. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |