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| Name | Class |
|---|---|
| Minia University | OTHER |
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The study aimed to investigate the efficacy of insulin in a new dosage form ( fast dissolving film) in treatment of anosmia in patients post infested with Covid-19. The study implication based in two methods evaluations
This study was designed to improve smell disorders after corona infection that is very anxious for all patients.
Inclusion criteria were loss of smell, post covid-19 infection, age from 18 to 70 years and accept sharing and follow up.
The application of dosage form by ENT specialist at otorhinolaryngology clinic at Minia University hospital. Dose was 100iu of insulin 3 times weekly for 4 weeks. The new dosage form with insulin was compared with a placebo to ensure statistical improvement.
The tests were performed in each visit. Primary outcome was the improvement of smell sensors in those patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Insulin fast dissolving film | Experimental | Formulated bioadhesive fast dissolving film contains 100IU of insulin |
|
| Plain fast dissolving film | Placebo Comparator | Formulated bioadhesive fast dissolving film contains no drug |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insulin film | Combination Product | Insulin suspension vials |
|
| Measure | Description | Time Frame |
|---|---|---|
| Smell sensation improvement | By decrease the threshold sensation with butanol test | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Soad Mohamed | Deraya | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Soad | Minya | 05637 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36063364 | Derived | Webster KE, O'Byrne L, MacKeith S, Philpott C, Hopkins C, Burton MJ. Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction. Cochrane Database Syst Rev. 2022 Sep 5;9(9):CD013877. doi: 10.1002/14651858.CD013877.pub3. | |
| 36062970 | Derived | O'Byrne L, Webster KE, MacKeith S, Philpott C, Hopkins C, Burton MJ. Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction. Cochrane Database Syst Rev. 2022 Sep 5;9(9):CD013876. doi: 10.1002/14651858.CD013876.pub3. |
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| ID | Term |
|---|---|
| D000086582 | Anosmia |
| ID | Term |
|---|---|
| D000857 | Olfaction Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Fast dissolving film | Device | Fast dissolving film |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |