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| Name | Class |
|---|---|
| Medical University of Graz | OTHER |
| Medical University of Vienna | OTHER |
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The aim of this study is to investigate the underlying inflammatory profile in patients with chronic lung disease and determine the association pulmonary hypertension.
Chronic lung diseases (CLD), such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are often complicated by the presence of pulmonary hypertension (PH), where even a mild elevation of blood pressure in the pulmonary arteries is associated with an even poorer prognosis. In this study, we will investigate whether similarities exist in the inflammatory profile that could potentially underlie all forms of pulmonary hypertension. Inflammatory data will be generated using flow cytometry, expression profiling and histological analysis and compared to the associated clinical data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD-PH group | Patients with confirmed COPD and pulmonary hypertension |
| |
| IPF-PH | Patients with confirmed pulmonary fibrosis and pulmonary hypertension |
| |
| Control group | Control group without diagnosed COPD, IPF, or pulmonary hypertension |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tissue sampling | Other | Blood collection via venipuncture into citrate- or ethylenediaminetetraacetic (EDTA)-containing vacutainer tubes and into serum tubes. Explant lung tissue obtained from patients that underwent lung transplantation. Non-transplanted donor lungs that had been harvested for transplantation, but not implanted because of size-reduction serve as controls. |
| Measure | Description | Time Frame |
|---|---|---|
| Analysis of inflammatory cell profile | The number of leukocytes (CD45+ cells) and derivatives (percentage lymphocytes, monocytes and neutrophils) will be measured by flow cytometry in explanted lung tissue and blood of patients with CLD-PH and controls. Values will be reported as %CD45+ and %total cells. | within 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Degree of pulmonary vascular disease | Pulmonary vascular disease will be assessed by associated clinical data (mPAP (mmHg), PVR (WU))
|
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Inclusion Criteria:
Exclusion Criteria:
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Subjects undergoing lung transplantation at the Medical University of Vienna
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Leigh Marsh | Contact | +4331638572911 | leigh.marsh@lvr.lbg.ac.at |
| Name | Affiliation | Role |
|---|---|---|
| Leigh Marsh | Ludwig Boltzmann Institute for Lung Vascular Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna | Recruiting | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D014652 | Vascular Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D002318 | Cardiovascular Diseases |
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Blood samples, explant lung tissue
|
| within 36 months |