Preventing Chemotherapy-induced Peripheral Neuropathy Using PRESIONA Exercise Program

Prevention of Chemotherapy-induced Peripheral Neuropathy With Therapeutic Exercise and Blood Flow Restriction Using PRESIONA Program

The aim of this study is to determinate if therapeutic exercise with blood flow restriction (BFR) during neoadjuvant chemotherapy potentialy neurotoxic could prevent the onset of chemotherapy induced peripheral neuropathy (CIPN) comparing to usual care.

CIPN is a side effect of cancer therapies that nowadays has no solution, so our intention is to carry out a preventive therapy against the onset of CIPN. The nature of the studies that try to prevent is very diverse, but one of the wide tools is therapeutic exercise. In this case we intend to combine therapeutic exercise with BFR to obtain a pre-conditioning effect that protects intraepidermal fibers from exposure to the chemotherapy.

Inclusion Criteria:

• 18 years or older
• HER2+ breast cancer diagnosis
• On the waiting list to anticancer medical treatment (taxanes-based neoadjuvant chemotherapy)

Exclusion Criteria:

• Previous diagnosis of cancer
• Pregnant
• Cardiac pathology
• No symptoms or pathology that could be confused with neuropathy or related to diabetes
• No recommendation from oncologist for therapeutic exercise practice