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The purpose of this study is to investigate the safety and clinical efficacy of HGP1910 and HCP1903 in patients with primary hypercholesterolemia
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HGP1910 | Experimental |
| |
| HCP1903 | Experimental |
| |
| HGP1909 | Active Comparator |
| |
| HGP1911 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HGP1910 | Drug | Take it once daily for 8 weeks orally. |
| |
| HCP1903 |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage change(%) from baseline in LDL-C at week 8 | baseline, 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage change(%) from baseline in LDL-C at week 4 | baseline, 4 weeks | |
| Percentage change(%) from baseline in LDL-C, TC, HDL-C, non-HDL-C | baseline, 4 weeks, 8 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34429197 | Derived | Lee SA, Kim W, Hong TJ, Ahn Y, Kim MH, Hong SJ, Kim BS, Kim SY, Chae IH, Kim BJ, Rhee MY, Shin JH, Kang TS, Cho JM, Kim JS, Lee CW. Effects of Fixed-dose Combination of Low-intensity Rosuvastatin and Ezetimibe Versus Moderate-intensity Rosuvastatin Monotherapy on Lipid Profiles in Patients With Hypercholesterolemia: A Randomized, Double-blind, Multicenter, Phase III Study. Clin Ther. 2021 Sep;43(9):1573-1589. doi: 10.1016/j.clinthera.2021.07.016. Epub 2021 Aug 21. |
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| Drug |
Take it once daily for 8 weeks orally. |
|
| HGP1909 | Drug | Take it once daily for 8 weeks orally. |
|
| HGP1911 | Drug | Take it once daily for 8 weeks orally. |
|
| Percentage change(%) from baseline in Apo A1, Apo B, lipoprotein (a) |
| baseline, 4 weeks, 8 weeks |
| Proportion of subjects achieving LDL-C treatment goals by cardiovascular Risk Category | baseline, 4 weeks, 8 weeks |