Research on the Effect and Mechanism of Aerobic Exercise... | NCT04651140 | Trialant

Research on the Effect and Mechanism of Aerobic Exercise... | NCT04651140 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Tremor group	Active Comparator	Participants in the tremor group have tremor as the main clinical manifestation	Behavioral: aerobic exercise
Stiff group	Active Comparator	Participants in the tremor group have stiff as the main clinical manifestation	Behavioral: aerobic exercise

Interventions

Name	Type	Description	Arm Group Labels	Other Names
aerobic exercise	Behavioral	Participants ride an Acon-8650 model exercise bicycle 3 times a week for 1 hour each time for four consecutive weeks	Stiff group Tremor group

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Movement Disorder Society-United Parkinson's Disease Rating Scale (MDS-UPDRS)	to assess the motor and nonmotor function of PD,0-200 scores,the higher scores mean lower function	changes of MDS-UPDRS score from baseline at four weeks
Montreal Cognitive Assessing(MoCA) score	to assess the cognitive function of PD,0-30 scores,the higher scores mean better function	changes of MoCA score from baseline at four weeks
The Epworth Sleeping Scale(ESS)	to assess the degree of drowsiness, 0-24 scores, the higher scores mean severe drowsiness	changes of ESS score from baseline at four weeks
Non-Motor Symptom Scale (NMSS)	to assess the non-motor of PD , 0-120 scores, the higher scores mean severe non-motor damage	changes of NMSS score from baseline at four weeks

Secondary Outcomes

Measure	Description	Time Frame
cerebral blood variation by Head MRI	to assess the cerebral blood variation by head MRI	changes of the cerebral blood from baseline at four weeks
cerebral blood flow velocity	cerebral blood flow velocity is recorded using transcranial Doppler and a servo-controlled plethysmograph respectively.

Contacts/Locations Module

Condition Browse Module

Intervention Browse Module