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| ID | Type | Description | Link |
|---|---|---|---|
| R201605453 | Other Grant/Funding Number | Revalidatiefonds |
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| Name | Class |
|---|---|
| Radboud University Medical Center | OTHER |
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Stroke survivors may have a latent, propulsive capacity of the paretic leg, that can be elicited during short, intensive gait training interventions. The aim of this study was therefor to investigate the effect of a five-week gait training on paretic propulsion, propulsion symmetry, gait capacity, and daily-life mobility and physical activity in chronic stroke survivors.
Stroke survivors may have a latent, propulsive capacity of the paretic leg, that can be elicited during short, intensive gait training interventions. The aim of this study was therefor to investigate the effect of a five-week gait training on paretic propulsion, propulsion symmetry, gait capacity, and daily-life mobility and physical activity in chronic stroke survivors. We hypothesize that the robotic gait training will improve propulsion symmetry and, thereby, gait speed and functional gait tasks. In addition, we expect that improved gait capacity might lead to less impact of stroke on daily-life mobility and a higher physical activity level. Thirty-three chronic stroke survivors with impaired paretic propulsion (≥8% difference in paretic vs. non-paretic propulsive impulse) will be enrolled in this proof-of-concept study. Participants receive five weeks individual robotic gait training targeting paretic propulsion (60 minutes, two time a week). The robotic gait training is complemented with daily home exercises (15 minutes/day) focusing on increasing strength and practice of learned strategies in daily life. Propulsion measures, self-selected gait speed, performance on functional gait tasks, and daily-life mobility and physical activity are assessed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gait training | Experimental | Participants receive five weeks individual robotic gait training in LOPES II, targeting paretic propulsion (60 minutes, two time a week). The robotic gait training is complemented with daily home exercises (15 minutes/day) focusing on increasing strength and practice of learned strategies in daily life. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gait training | Device | Participants receive five weeks individual robotic gait training in LOPES II, targeting paretic propulsion (60 minutes, two time a week). The robotic gait training is complemented with daily home exercises (15 minutes/day) focusing on increasing strength and practice of learned strategies in daily life. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in propulsion symmetry at self-selected gait speed between pre- and post-intervention | Propulsion symmetry was calculated by dividing the paretic propulsive impulse by the sum of the paretic and non-paretic propulsive impulse | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in self-selected gait speed between pre- and post-intervention | Participants walked at their self-selected, comfortable speed along a straight six-meter walkway. Gait speed was determined in m/s. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ACH Geurts, Prof. dr. | Radboud University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sint Maartenskliniek | Ubbergen | Gelderland | 6574NA | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33892754 | Derived | Alingh JF, Groen BE, Kamphuis JF, Geurts ACH, Weerdesteyn V. Task-specific training for improving propulsion symmetry and gait speed in people in the chronic phase after stroke: a proof-of-concept study. J Neuroeng Rehabil. 2021 Apr 23;18(1):69. doi: 10.1186/s12984-021-00858-8. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Longitudinal intervention study with two consecutive baseline assessments and a five-week follow-up
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| Change in trailing limb angle of the paretic leg between pre- and post-intervention | The position of the hip joint center and toe marker, determined with a 3D gait analysis, were used to calculate the trailing limb angle (in degrees) of the paretic leg at the instant of peak paretic anterior ground reaction force. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Change in ankle plantarflexion moment of the paretic leg between pre- and post-intervention | Vicon Plug-In-Gait model and software were used to calculate paretic ankle plantarflexion moment (Nm/kg) at the instant of peak paretic anterior ground reaction force. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Change in performance on the Six-minute walk test between pre- and post-intervention | Six-minute walk test (meters) was performed. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Change in performance on the Functional gait assessment between pre- and post-intervention | Functional gait assessment (score range 0-30) was performed. Higher scores indicate better outcome. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Change in daily-life mobility between pre- and post-intervention | Daily-life mobility was assessed with the Stroke Impact Scale (SIS - domain Mobility, range 0-100). Higher scores indicate better outcome. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Change in daily-life physical activity between pre- and post-intervention | Daily-life physical activity was assesed using an activity-tracker (Activ8). Participants wore the activity tracker for 24 hours a day, for a minimum of five consecutive days. Total time of walking and the intensity of walking were determined. | Assessments are performed five weeks (T0) and one week (T1) before the start of the intervention, and one week (T2) and five weeks (T3) after the end of the five-week intervention period. |
| Static postural balance at baseline | To determine the association between individuals' baseline characteristics and the training response the determinant was assessed during stance using forceplates at T0. | Assessments are performed five weeks (T0) before the start of the intervention. |
| The difference in propulsion impulse of the paretic leg during walking at fast vs. self-selected speed at baseline | To determine the association between individuals' baseline characteristics and the training response the determinant was assessed during the 3D-gait analysis at T0. | Assessments are performed five weeks (T0) before the start of the intervention. |
| Maximal ankle plantarflexion moment at baseline | To determine the association between individuals' baseline characteristics and the training response the determinant was assessed with the Biodex at T0. | Assessments are performed five weeks (T0) before the start of the intervention. |
| Score on the maximal steplength test at baseline | To determine the association between individuals' baseline characteristics and the training response the determinant was assessed at T0. | Assessments are performed five weeks (T0) before the start of the intervention. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |