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The G-NUH registry is a two-center, real-world registry of percutaneous coronary intervention in patients with significant coronary artery disease. From January 2010, PCI-treated patients from Gyeonsang National University Hospitals (Jinju & Changwon) were enrolled in this registry.
The aim of this registry is to investigate long-term clinical outcomes and predictors of adverse outcomes after percutaneous coronary intervention from the academic hospitals.
In the G-NUH registry, the investigators have collected and measured multiple hemostatic, physiologic and laboratory measurements (on-admission & 1-month) and questionnarred from PCI-treated patients. This registry will focus on the impacts of these parameters on long-term clinical outcomes from East Asian patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| stent, ballooning | Device | DES, BMS, BRS, DEB, and POBA can be used for PCI |
| Measure | Description | Time Frame |
|---|---|---|
| MACE | the composite of cardiovascular death, myocardial infarction or stroke | up to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular death | Mortality related with cardiovascular events | up to 10 years |
| Myocardial infarction | Fatal & non-fatal myocardial infarction |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of MACE according to platelet function | VerifyNow assay | up to 10 years |
| Incidence of MACE according to global hemostasis assay | thromboelastography (TEG: R, alpha angle, MA and LY30) |
Inclusion Criteria:
Exclusion Criteria:
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The GNUH registry is focused on clinical impact of multiple hemostatic, physiologic and laboratory measurements on CAD patients treated with PCI.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jin Sin Koh, MD, PhD | Contact | 82-10-8544-0175 | kjs0175@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Young-Hoon Jeong, MD, PhD | Changwon Gyeongsang National University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changwon Gyeongsang National University Hospital | Recruiting | Changwon | Gyeongsangnam-do | 51472 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32279217 | Result | Bae JS, Ahn JH, Jang JY, Cho SY, Kang MG, Kim KH, Park HW, Koh JS, Park Y, Hwang SJ, Kwak CH, Hwang JY, Tantry US, Gurbel PA, Jeong YH. The Impact of platelet-fibrin clot strength on occurrence and clinical outcomes of peripheral artery disease in patients with significant coronary artery disease. J Thromb Thrombolysis. 2020 Nov;50(4):969-981. doi: 10.1007/s11239-020-02103-w. | |
| 41953291 |
| Label | URL |
|---|---|
| Analysis from the G-NUH registry | View source |
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This registry would be shared with other researchers in terms of whole collected data.
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| ID | Term |
|---|---|
| D020141 | Hemostatic Disorders |
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
| D006402 | Hematologic Diseases |
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| ID | Term |
|---|---|
| D015607 | Stents |
| ID | Term |
|---|---|
| D019736 | Prostheses and Implants |
| D004864 | Equipment and Supplies |
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After we receive patients' approval, their blood would be collected before PCI. The blood will be stored in Biobank (Gyeongsang National University Hospital).
| up to 10 years |
| Stroke | Ischemic & hemorrhagic stroke | up to 10 years |
| Revascularization | target-lesion, target-vessel vs. nontarget-vessel | up to 10 years |
| Major bleeding | BARC type 3-5 | up to 10 years |
| Stent thrombosis | Thrombotic events in & near to stent | up to 10 years |
| ISR | in-stent restenosis | up to 10 years |
| up to 10 years |
| Incidence of MACE according to hemostatic biomarkers | hs-CRP, fibrinogen, D-dimer, NT-proBNP, lipid battery | up to 10 years |
| Incidence of MACE according to cardiac contractility | Echocardiography: LV EF, E/A, TR Vmax, LAVI | up to 10 years |
| Incidence of MACE according to physiologic index | fractional flow reserve (FFR), coronary flow reserve (CFR) and the index of microvascular resistance (IMR) | up to 10 years |
| Incidence of MACE according to 1-month bleeding & dyspnea episodes | Qestionnarres for bleeding, dyspnea, side effects | up to 10 years |
| Gyeonsang National University Hospital | Recruiting | Jinju | Gyeonsangnam-do | South Korea |
|
| Derived |
| Kim BS, Ahn JH, Kang MG, Kim KH, Bae JS, Cho YH, Koh JS, Cho EJ, Kim SW, Tantry US, Gurbel PA, Hwang JY, Shin JH, Jeong YH. Arterial stiffness index and blood pressure phenotypes in patients undergoing percutaneous coronary intervention: prognostic implications for ischemic and bleeding events. Clin Hypertens. 2026 Apr 1;32:e15. doi: 10.5646/ch.2026.32.e15. eCollection 2026. |
| 41483545 | Derived | Cho JH, Ahn JH, Kang MG, Bae JS, Koh JS, Jung MK, Kim SW, Gorog DA, Tantry US, Gurbel PA, Kim W, Hwang JY, Jeong YH. Residual Cardiovascular Biomarkers After Medical Therapy and Their Prognostic Implications Following Percutaneous Coronary Intervention. JACC Adv. 2026 Feb;5(2):102498. doi: 10.1016/j.jacadv.2025.102498. Epub 2026 Jan 2. |
| 40910963 | Derived | Omar M, Kang MG, Jung MK, Ahn JH, Koh JS, Guevarra PI, Kim SW, Tantry US, Gurbel PA, Hwang JY, Jeong YH. Association and Prognostic Implications of "No-Reflow Phenomenon" and Hypercoagulability in Patients With ST-Segment Elevation Myocardial Infarction. JACC Asia. 2025 Nov;5(11):1487-1501. doi: 10.1016/j.jacasi.2025.07.015. Epub 2025 Sep 5. |
| 40139850 | Derived | Cho S, Jung M, Ahn JH, Kang MG, Bae JS, Koh JS, Hwang SJ, Kim HS, Kim SW, Hwang JY, Jeong YH. Diabetic Status and Thrombogenicity: Association and Prognostic Implications After Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2025 Mar 24;18(6):720-733. doi: 10.1016/j.jcin.2024.12.002. |
| 38841588 | Derived | Lee SY, Cho JY, Gorog DA, Angiolillo DJ, Yun KH, Ahn JH, Koh JS, Park Y, Hwang SJ, Hwang JY, Kim JW, Jang Y, Jeong YH. Inflammation and platelet reactivity during adjunctive colchicine versus aspirin in patients with acute coronary syndrome treated with potent P2Y12 inhibitor. Front Med (Lausanne). 2024 Apr 19;11:1349577. doi: 10.3389/fmed.2024.1349577. eCollection 2024. |
| 36857519 | Derived | Lee SH, Kim HK, Ahn JH, Kang MG, Kim KH, Bae JS, Cho SY, Koh JS, Park Y, Hwang SJ, Gorog DA, Tantry US, Bliden KP, Gurbel PA, Hwang JY, Jeong YH. Prognostic impact of hypercoagulability and impaired fibrinolysis in acute myocardial infarction. Eur Heart J. 2023 May 14;44(19):1718-1728. doi: 10.1093/eurheartj/ehad088. |
| 36338415 | Derived | Ahn JH, Tantry US, Kang MG, Park HW, Koh JS, Bae JS, Cho SY, Kim KH, Jang JY, Park JR, Park Y, Hwang SJ, Kwak CH, Hwang JY, Gurbel PA, Jeong YH. Residual Inflammatory Risk and its Association With Events in East Asian Patients After Coronary Intervention. JACC Asia. 2022 Apr 12;2(3):323-337. doi: 10.1016/j.jacasi.2021.11.014. eCollection 2022 Jun. |
| D006425 |
| Hemic and Lymphatic Diseases |
| D016769 | Embolism and Thrombosis |