Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Boehringer Ingelheim | INDUSTRY |
| Norwegian University of Science and Technology | OTHER |
| Vestre Viken Hospital Trust | OTHER |
Not provided
Not provided
Not provided
Not provided
In this population study aim is to evaluate risk factors for heart failure and combine these into a new heart failure risk score.
Secondly, the heart failure risk score will be internally and externally validated, and compared with established heart failure risk scores. Additionally, the prevalence of heart failure as well as the distribution of the heart failure risk score in the general population will be evaluated.
Explore which clinical risk factors or patient characteristics in a general population that are associated with increased risk for heart failure events and combine these into a new population-based heart failure risk score ("The HUNT for heart failure risk score") for predicting heart failure risk
Validate the newly developed heart failure risk score internally in the HUNT2 database
Compare the predictive ability of the new heart failure risk score with established heart failure risk scores (the ABC Health HF risk score, the Framingham HF risk score) and an established Norwegian cardiovascular risk score (NORRISK 2)
Estimate the prevalence of likely ("undiagnosed") heart failure , i.e., patients at high risk of HF, in a general population by using both the established heart failure risk scores and the newly developed heart failure risk score, and compare the heart failure event rate between those at high risk of heart failure and those with established heart failure.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants in the third wave of the HUNT study | General population participating in the third wave of the HUNT study |
| |
| Participants in the second wave of the HUNT study | General population participating in the second wave of the HUNT study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heart failure risk estimation | Other | Evaluation by heart failure risk score |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to incident heart failure event | Time to first heart failure hospitalization or heart failure related visit at the out-patient clinic (events defined according to the ESC 2016 heart failure guidelines) | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Time to death from any cause | Time to death from any cause | 10 years |
| Time to first heart failure event or death from any cause | Time to first heart failure event (hospitalization or HF related visit at the out-patient clinic) or death from any cause |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of heart failure | Prevalence of heart failure in a general population | 0 days |
| Distribution of heart failure risk score categories | Distribution of the heart failure risk score categories in a general population |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
General population
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Håvard Dalen, MSc, PhD | Helse Nord-Trøndelag HF | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Levanger hospital | Levanger | Norge | 7600 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37248650 | Derived | Ofstad AP, Brunborg C, Johansen OE, Morkedal B, Fagerland MW, Laugsand LE, Gullestad LL, Dalen H. Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score. ESC Heart Fail. 2023 Oct;10(5):2807-2815. doi: 10.1002/ehf2.14390. Epub 2023 May 29. |
Not provided
Not provided
Will follow the institutional regulations
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D004194 | Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Biobank available, but not included in this project. Laboratory test made available are haematology overview, renal function serology, C-reactive protein
| 10 years |
| Validity of heart failure risk score | Evaluation of the validity of heart failure risk score | 10 years |
| 0 days |