The Effects of Wild Blueberries on Depressive Symptoms in Young Adults

The Effects of Wild Blueberries on Depressive Symptoms in Young Adults: a Randomized, Double-blind, Placebo-controlled Trial

This study aims to investigate the effects of a 6-week dietary intervention of 22 g freeze-dried whole wild blueberry powder. The outcomes include measures of depression, anxiety, anhedonia, cognitive function, and biomarkers of inflammation and oxidative stress.

A randomized, double-blind, placebo-controlled, parallel-design study assessing the effects of a 6-week intervention of wild blueberry powder in young adults with depressive symptoms. A total of 60 participants will be randomly assigned to either 22 g blueberry powder or a matched placebo powder consumed daily with water. The severity of depression, anxiety, anhedonia, perceived stress, and quality of life will be measured at baseline and 6 weeks later. In addition, we will assess changes in cognitive function and transient mood 2 hours after consuming a single dose of blueberries.

Inclusion Criteria:

• 18 to 24 years of age
• Patient Health Questionnaire-9 score ≥ 10 and a score ≥ 2 on the sum of items 1 and 2
• Willingness to provide blood samples

Exclusion Criteria:

• Any medically significant condition (e.g. diabetes, endocrine or gastrointestinal disorders)
• Taking medication (excluding hormonal contraception)
• History of mental illness (excluding anxiety and unipolar depressive disorders)
• Allergy to blueberries or any other Vaccinium species
• Receiving psychotherapy or counselling