Effort-Lung Ultra Sound

Positive Diagnosis of Heart Failure With Preserved LVEF by Exercise Pulmonary Ultrasound.

The E-LUS study is a prospective, non randomised, monocenter case-control study.

The main objective is to evaluate the association of exercise lung ultrasound data acquired during a stress test on a bicycle ergometer with the diagnosis of heart failure with preserved ejection fraction (HFpEF).

Secondary objectives:

1. To assess the diagnostic performance of exercise lung ultrasound for the diagnosis of HFpEF.
2. To identify the value of the B-lines score on exercise maximizing the sensitivity and specificity for the diagnosis of HFpEF.
3. To evaluate the relationship of the delta of B-lines scores between rest and exercise with the diagnosis of HFpEF.
4. To assess the diagnostic performance of the delta of B-lines between rest and exercise for the diagnosis of HFpEF.
5. To identify the score of the delta of B-lines value between rest and exercise maximizing sensitivity and specificity for the diagnosis of HFpEF.
6. To evaluate the relationship between the resting value of the B-lines scores with the diagnosis of HFpEF.
7. To assess the diagnostic performance of the resting lung ultrasound for the diagnosis of HFpEF.
8. To identify the value of the B-lines score at rest maximizing the sensitivity and specificity for the diagnosis of HFpEF.
9. To evaluate the correlation between the B-line score measured at rest and exercise and the dyspnoea score measured at rest, during exercise, and during the recovery phase.
10. To assess the correlation of the delta of B-lines scores between rest and exercise and the dyspnoea score measured at rest, during exercise and during the recovery phase.

Inclusion Criteria (Control group) :

• Patients 65 years of age and older scheduled for a stress test.
• Never diagnosed with either preserved or altered ejection fraction heart failure
• Non-dyspneic (New York Heart Association class I)

Inclusion Criteria (Case group) :

• Patients 65 years of age and older scheduled for a stress test.
• Patients already diagnosed with HFpEF following hospitalization for heart failure (LVEF>50%)

Exclusion Criteria:

• Patients who are opposed to participate to the research project / the use of their data,
• Pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images (e.g. pulmonary fibrosis, diffuse interstitial lung disease or lung cancer)
• Patients with a history of thoracic surgery
• Patients under legal protection measures (guardianship, curator, judicial safeguard),
• Pregnant women, parturient women or nursing mothers,
• Patients who are unable to express consent,
• Persons deprived of their liberty by a judicial or administrative decision,
• Persons subject to psychiatric care,
• Patients discharged from hospital for a worsening heart failure hospitalization for less than 15 days