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This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course
This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| non-COVID sepsis | Patients admitted to ICU with sepsis of non-COVID origin |
| |
| COVID sepsis | Patients admitted to ICU with sepsis of COVID origin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| microcirculation recording | Diagnostic Test | non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in Proportion of Perfused Vessels (PPV) parameter | PPV describes microcirculation dysfunction | 1st, 2nd and 3rd day |
| change in Syndecan-1 serum concentration | Syndecan-1 is a marker of endothelial glycocalyx | 1st, 2nd and 3rd day |
| Measure | Description | Time Frame |
|---|---|---|
| change in albuminuria | albuminuria is a marker of glomerular endothelial cells dysfunction | 1st, 2nd and 3rd day |
| mortality in 28 days | mortality in 28 days from ICU admission |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients admitted to the ICU with signs of circulatory instability with any method of organ support. Patients expected to have a particular method of organ support for at least 3 days.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Hradec Kralove | Hradec Králové | Třebeš | 50005 | Czechia |
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| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D018805 | Sepsis |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
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serum
|
| 30 days |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |