Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis

Circulatory and Endothelial Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis - Prospective, Observational Pilot Study

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.

Inclusion Criteria:

• adult
• ICU admission due to sepsis with organ failure
• need for organ support therapy (mechanical ventilation, CRRT, ECMO)
• clinical and/or laboratory signs of circulatory instability

Exclusion Criteria:

• family withdrawal/disagreement
• death within three days from ICU admission