Nipple-sparing mastectomy (NSM) with immediate breast reconstruction (IBR) is a form of mastectomy that achieves optimal disease control and facilitates reconstruction. The study aimed to assess the oncological safety and aesthetic outcomes of nipple-sparing mastectomy and immediate breast reconstruction.

35 female patients with breast cancer were included in the study. The investigators categorized the incisions into radial, inframammary, and periareolar incisions with planned reconstruction types; direct to implant (DTI), transversus rectus abdominis myocutaneous (TRAM) flap, latissimus dorsi myocutaneous (LD) flap, or LD with implant.

Inclusion Criteria:

• Diagnosis of ductal in situ carcinoma or infiltrating ductal carcinoma with a tumor diameter up to 3 cm
• Distance of the tumor from the nipple ≥ 2 cm
• Cancer or microcalcifications not localized in the central field.
• No blood secretions or other (nipple-areola complex) NAC disturbances
• Absence of skin involvement
• Indication to mastectomy for multifocal or diffuse microcalcifications
• Negative intraoperative assessment of NAC-bottom

Exclusion Criteria:

• Tumor or microcalcifications localized in the central quadrant or in the retroareolar region
• Blood secretions or other NAC alterations
• Positive intraoperative assessment of NAC-bottom
• Inflammatory carcinoma
• Paget's disease of the nipple

The mean age of the studied patients was 44.00±9.47 years old; the youngest patient was 28 years old and the oldest one was 68 years old, the majority of patients were 40-50 years of age (54%) As regard the patients' marital status; 31 patients were married constituting 88.57 % and only 4 (11.4 %) patients were single The main complaint of 25 of them (71.42%) was painless breast lump while 8 cases (22.85%) presented with local recurrence after previous breast conservative surgery and only two case (5.7%) presented by extensive mammographic calcifications on screening mammography